比较转录组分析揭示了鹅(Anser anser)胚胎发育过程中黑色素分布的关键基因。

IF 1.6 3区 农林科学 Q2 AGRICULTURE, DAIRY & ANIMAL SCIENCE British Poultry Science Pub Date : 2024-08-01 Epub Date: 2024-05-15 DOI:10.1080/00071668.2024.2335943
Y Yang, C Wang, Y Liu, G Li, X Wang, H Wang, D He
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引用次数: 0

摘要

1.黑色素的分布通常沿着身体的背腹轴呈梯度稀释,家鹅也是如此。2. 转录组比较在三个胚胎阶段进行,特别是胚胎第 15 (E15)、22 (E22) 和 29 (E29)天,在色素沉着的背侧皮肤和色素脱失的远足之间进行。发现了与黑色素合成相关的差异表达基因(DEGs),尤其是 TYR、TYRP1 和 EDNRB2,它们在 E15 和 E22 期的背侧皮肤中的表达水平显著较高。4. ASIP 基因在 E22 阶段后在远足皮肤的表达水平明显高于在背侧皮肤的表达水平(E22/E29 阶段的 log2FC:5.31/6.88)。基因本体(GO)富集分析检测到八个与黑色素合成和黑色素小体形成相关的术语(p
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Comparative transcriptomic analyses reveal key genes underlying melanin distribution during embryonic development in geese (Anser anser).

1. Melanin distribution typically exhibits a gradient dilution along the dorsal-ventral axis of the body, including in domestic geese. However, the specific genes and molecular mechanisms responsible for this melanin distribution pattern remain incompletely understood.2. The transcriptomic comparisons were conducted at three embryonic stages, specifically on embryonic d 15 (E15), 22 (E22), and 29 (E29), between the pigmented dorsal skin and the depigmented distal foot.3. Differentially expressed genes (DEGs) associated with melanin synthesis were identified, particularly TYR, TYRP1, and EDNRB2, which exhibited significantly higher expression levels in the dorsal skin at E15 and E22. However, expression levels significantly decreased in later stages (E29).4. The ASIP gene showed remarkably high-expression levels in the distal feet compared to the dorsal skin post-E22 stage (log2FC: 5.31/6.88 at E22/E29). Gene Ontology (GO) enrichment analysis detected eight terms associated with melanin synthesis and melanosome formation (p < 0.05), including melanosome membrane (GO: 0033162) and melanin biosynthetic process (GO: 0042438). Additionally, KEGG pathway analysis showed significant enrichment of the melanogenesis pathway (hsa004916) at d 22 (E22).

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来源期刊
British Poultry Science
British Poultry Science 农林科学-奶制品与动物科学
CiteScore
3.90
自引率
5.00%
发文量
88
审稿时长
4.5 months
期刊介绍: From its first volume in 1960, British Poultry Science has been a leading international journal for poultry scientists and advisers to the poultry industry throughout the world. Over 60% of the independently refereed papers published originate outside the UK. Most typically they report the results of biological studies with an experimental approach which either make an original contribution to fundamental science or are of obvious application to the industry. Subjects which are covered include: anatomy, embryology, biochemistry, biophysics, physiology, reproduction and genetics, behaviour, microbiology, endocrinology, nutrition, environmental science, food science, feeding stuffs and feeding, management and housing welfare, breeding, hatching, poultry meat and egg yields and quality.Papers that adopt a modelling approach or describe the scientific background to new equipment or apparatus directly relevant to the industry are also published. The journal also features rapid publication of Short Communications. Summaries of papers presented at the Spring Meeting of the UK Branch of the WPSA are published in British Poultry Abstracts .
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