路易体痴呆症和阿尔茨海默氏症患者抑郁的神经解剖学基础。

IF 5.3 2区 医学 Q1 GERIATRICS & GERONTOLOGY GeroScience Pub Date : 2024-12-01 Epub Date: 2024-05-15 DOI:10.1007/s11357-024-01190-4
Manon Querry, Anne Botzung, Benjamin Cretin, Catherine Demuynck, Candice Muller, Alix Ravier, Benoît Schorr, Mary Mondino, Léa Sanna, Paulo Loureiro de Sousa, Nathalie Philippi, Frédéric Blanc
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引用次数: 0

摘要

路易体痴呆(DLB)和阿尔茨海默病(AD)从前驱期开始就经常伴有抑郁症状。本研究旨在调查前驱期至轻度 DLB 患者与 AD 患者相比抑郁症的神经解剖相关性。本研究共招募了 83 名 DLB 患者、37 名 AD 患者和 18 名健康志愿者。所有参与者均获得了 T1 加权三维解剖图像。使用基于体素的全脑形态测量(VBM)方法对灰质体积(GMV)进行了回归和比较分析。DLB患者的平均MINI评分明显高于AD患者(p = 0.004),30.1%的DLB患者患有临床抑郁症,56.6%的患者有抑郁症病史,而0%的AD患者患有临床抑郁症,29.7%的患者有抑郁症病史。VBM回归分析显示,DLB患者的MINI评分与右侧前额叶区域的GMV呈负相关(p
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Neuroanatomical substrates of depression in dementia with Lewy bodies and Alzheimer's disease.

Dementia with Lewy bodies (DLB) and Alzheimer's disease (AD) are often associated with depressive symptoms from the prodromal stage. The aim of the present study was to investigate the neuroanatomical correlates of depression in prodromal to mild DLB patients compared with AD patients. Eighty-three DLB patients, 37 AD patients, and 18 healthy volunteers were enrolled in this study. Depression was evaluated with the Mini International Neuropsychiatric Interview (MINI), French version 5.0.0. T1-weighted three-dimensional anatomical images were acquired for all participants. Regression and comparison analyses were conducted using a whole-brain voxel-based morphometry (VBM) approach on the grey matter volume (GMV). DLB patients presented a significantly higher mean MINI score than AD patients (p = 0.004), 30.1% of DLB patients had clinical depression, and 56.6% had a history of depression, while 0% of AD patients had clinical depression and 29.7% had a history of depression. VBM regression analyses revealed negative correlations between the MINI score and the GMV of right prefrontal regions in DLB patients (p < 0.001, uncorrected). Comparison analyses between DLB patients taking and those not taking an antidepressant mainly highlighted a decreased GMV in the bilateral middle/inferior temporal gyrus (p < 0.001, uncorrected) in treated DLB patients. In line with the literature, our behavioral analyses revealed higher depression scores in DLB patients than in AD patients. We also showed that depressive symptoms in DLB are associated with decreased GMV in right prefrontal regions. Treated DLB patients with long-standing depression would be more likely to experience GMV loss in the bilateral middle/inferior temporal cortex. These findings should be taken into account when managing DLB patients.

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来源期刊
GeroScience
GeroScience Medicine-Complementary and Alternative Medicine
CiteScore
10.50
自引率
5.40%
发文量
182
期刊介绍: GeroScience is a bi-monthly, international, peer-reviewed journal that publishes articles related to research in the biology of aging and research on biomedical applications that impact aging. The scope of articles to be considered include evolutionary biology, biophysics, genetics, genomics, proteomics, molecular biology, cell biology, biochemistry, endocrinology, immunology, physiology, pharmacology, neuroscience, and psychology.
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