鸡体内 N-乙酰-L-半胱氨酸的药代动力学。

IF 1.5 4区 农林科学 Q3 PHARMACOLOGY & PHARMACY Journal of veterinary pharmacology and therapeutics Pub Date : 2024-05-15 DOI:10.1111/jvp.13452
Albena Roydeva, Gabriela Beleva, Daniel Gadzhakov, Aneliya Milanova
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引用次数: 0

摘要

N-acetyl-l-cysteine (NAC) 被认为是一种抗氧化剂,可减轻肉鸡应激条件的负面影响。然而,人们对其在禽类中的药代动力学(PK)了解非常有限。因此,本研究旨在进一步阐明 NAC 在鸡体内的 PK 特性。对肉鸡进行单次静脉注射(i.v.)或口服(p.o.)治疗,或通过饲料多次给药 NAC。通过 LC-MS/MS 测定药物浓度,并对数据进行非室分析和非线性混合效应建模。经静脉注射后,NAC可在短时间内被排出体外,t1/2el为0.93(0.59-2.09)小时。NAC的分布有限,其在中心区和外周区的群体平均分布容积V1和V2分别为0.148升/千克和0.199升/千克,Vdarea为0.39(0.258-0.635)升/千克。MRT 值为 1.76 h(范围为 0.96-2.69,p
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Pharmacokinetics of N-acetyl-l-cysteine in chickens

N-acetyl-l-cysteine (NAC) has been suggested as an antioxidant that can alleviate the negative effects of stress conditions in broilers. However, knowledge of its pharmacokinetics (PK) in this avian species is very limited. Therefore, the study aimed to shed more light on the PK properties of NAC in chickens. Broilers were subjected to single intravenous (i.v.) or oral (p.o.) treatment or multiple NAC administrations via the feed. Drug concentrations were determined by LC–MS/MS, and the data were subjected to non-compartmental analysis and modeled by non-linear mixed effect approach. NAC was eliminated in a short time after i.v. treatment, with a t 1/2el of 0.93 (0.59–2.09) h. It showed limited distribution with population mean of volumes of distribution in the central and peripheral compartments V 1 of 0.148 L/kg and V 2 of 0.199 L/kg, respectively, and V darea of 0.39 (0.258–0.635) L/kg. The value of MRT was 1.76 h (range of 0.96–2.69, p < .05) after single p.o. treatment, indicating a twofold increase if compared to i.v. administration (0.87 h, 0.55–1.78). Both methods of Pk analysis revealed very limited bioavailability, <10%. Feeding behavior led to a later achievement of lower maximum plasma concentrations (5.74, range of 3.44–9.32 μg/mL, p < .05), which were maintained during the 5 days of treatment.

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来源期刊
CiteScore
3.10
自引率
15.40%
发文量
69
审稿时长
8-16 weeks
期刊介绍: The Journal of Veterinary Pharmacology and Therapeutics (JVPT) is an international journal devoted to the publication of scientific papers in the basic and clinical aspects of veterinary pharmacology and toxicology, whether the study is in vitro, in vivo, ex vivo or in silico. The Journal is a forum for recent scientific information and developments in the discipline of veterinary pharmacology, including toxicology and therapeutics. Studies that are entirely in vitro will not be considered within the scope of JVPT unless the study has direct relevance to the use of the drug (including toxicants and feed additives) in veterinary species, or that it can be clearly demonstrated that a similar outcome would be expected in vivo. These studies should consider approved or widely used veterinary drugs and/or drugs with broad applicability to veterinary species.
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