破解 Wnt 核难题

IF 81.3 1区 生物学 Q1 CELL BIOLOGY Nature Reviews Molecular Cell Biology Pub Date : 2024-05-17 DOI:10.1038/s41580-024-00747-7
Esther M. Verheyen, Cara J. Gottardi
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引用次数: 0

摘要

Verheyen和Gottardi重温了Basler、Peifer和Clevers实验室的两篇开创性论文,这两篇论文阐明了核β-catenin通过与Wnt靶基因上的TCF相互作用在Wnt信号转导中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Solving the Wnt nuclear puzzle
Verheyen and Gottardi revisit two seminal papers by the Basler, Peifer and Clevers labs elucidating the role of nuclear β-catenin in Wnt signal transduction through its interaction with TCF at Wnt target genes.
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来源期刊
Nature Reviews Molecular Cell Biology
Nature Reviews Molecular Cell Biology 生物-细胞生物学
CiteScore
173.60
自引率
0.50%
发文量
118
审稿时长
6-12 weeks
期刊介绍: Nature Reviews Molecular Cell Biology is a prestigious journal that aims to be the primary source of reviews and commentaries for the scientific communities it serves. The journal strives to publish articles that are authoritative, accessible, and enriched with easily understandable figures, tables, and other display items. The goal is to provide an unparalleled service to authors, referees, and readers, and the journal works diligently to maximize the usefulness and impact of each article. Nature Reviews Molecular Cell Biology publishes a variety of article types, including Reviews, Perspectives, Comments, and Research Highlights, all of which are relevant to molecular and cell biologists. The journal's broad scope ensures that the articles it publishes reach the widest possible audience.
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