{"title":"评估成人和儿童阻塞性睡眠呼吸暂停患者的血清/血浆白细胞介素(IL-6、IL-12、IL-17、IL-18 和 IL-23)水平:系统综述、元分析和试验序列分析》。","authors":"Amin Golshah, Masoud Sadeghi, Edris Sadeghi","doi":"10.1089/jir.2024.0057","DOIUrl":null,"url":null,"abstract":"<p><p>Obstructive sleep apnea (OSA) is a chronic inflammatory disease characterized by partial or complete upper airway obstruction during sleep. We aimed to evaluate serum/plasma levels of several cytokines (interleukin [IL]-6, IL-12, IL-17, IL-18, and IL-23) in a systematic review meta-analysis in both adults and children with OSA compared with controls. We conducted a comprehensive search of 4 digital databases (PubMed, Web of Science, Scopus, and Cochrane Library) up until October 19, 2023, without any limitations. For our meta-analysis, we used Review Manager, version 5.3, and displayed the data as the standardized mean difference (SMD) and 95% confidence interval (CI) to assess the correlation between cytokine levels and OSA. We utilized Comprehensive Meta-Analysis version 3.0 software to conduct bias analyses, meta-regression, and sensitivity analyses. From 1881 records, 84 articles were included in the systematic review and meta-analysis. In adults, the pooled SMDs for IL-6 level were 0.79 (<i>P</i> value < 0.00001), for IL-17 level were 0.74 (<i>P</i> value = 0.14), and for IL-18 level were 0.43 (<i>P</i> value = 0.00002). In children, the pooled SMD for IL-6 was 1.10 (<i>P</i> value < 0.00001), for IL-12 was 0.47 (<i>P</i> value = 0.10), for IL-17 was 2.21 (a <i>P</i> value = 0.24), for IL-18 was 0.19 (<i>P</i> value = 0.07), and for IL-23 was 2.46 (<i>P</i> value < 0.0001). The subgroup analysis showed that the ethnicity, mean body mass index, and mean apnea-hypopnea index for IL-6 levels in adults and the ethnicity for IL-6 levels in children were effective factors in the pooled SMD. The findings of the trial sequential analysis revealed that adequate evidence has been obtained. The analysis of IL levels in adults and children with OSA compared with those without OSA revealed significant differences. In adults, IL-6 and IL-18 levels were significantly higher in the OSA group, while in children, only IL-6 and IL-23 levels were significantly elevated.</p>","PeriodicalId":16261,"journal":{"name":"Journal of Interferon and Cytokine Research","volume":" ","pages":"300-315"},"PeriodicalIF":1.9000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Evaluation of Serum/Plasma Levels of Interleukins (IL-6, IL-12, IL-17, IL-18, and IL-23) in Adults and Children with Obstructive Sleep Apnea: A Systematic Review, Meta-Analysis, and Trial Sequential Analysis.\",\"authors\":\"Amin Golshah, Masoud Sadeghi, Edris Sadeghi\",\"doi\":\"10.1089/jir.2024.0057\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Obstructive sleep apnea (OSA) is a chronic inflammatory disease characterized by partial or complete upper airway obstruction during sleep. We aimed to evaluate serum/plasma levels of several cytokines (interleukin [IL]-6, IL-12, IL-17, IL-18, and IL-23) in a systematic review meta-analysis in both adults and children with OSA compared with controls. We conducted a comprehensive search of 4 digital databases (PubMed, Web of Science, Scopus, and Cochrane Library) up until October 19, 2023, without any limitations. For our meta-analysis, we used Review Manager, version 5.3, and displayed the data as the standardized mean difference (SMD) and 95% confidence interval (CI) to assess the correlation between cytokine levels and OSA. We utilized Comprehensive Meta-Analysis version 3.0 software to conduct bias analyses, meta-regression, and sensitivity analyses. From 1881 records, 84 articles were included in the systematic review and meta-analysis. In adults, the pooled SMDs for IL-6 level were 0.79 (<i>P</i> value < 0.00001), for IL-17 level were 0.74 (<i>P</i> value = 0.14), and for IL-18 level were 0.43 (<i>P</i> value = 0.00002). In children, the pooled SMD for IL-6 was 1.10 (<i>P</i> value < 0.00001), for IL-12 was 0.47 (<i>P</i> value = 0.10), for IL-17 was 2.21 (a <i>P</i> value = 0.24), for IL-18 was 0.19 (<i>P</i> value = 0.07), and for IL-23 was 2.46 (<i>P</i> value < 0.0001). The subgroup analysis showed that the ethnicity, mean body mass index, and mean apnea-hypopnea index for IL-6 levels in adults and the ethnicity for IL-6 levels in children were effective factors in the pooled SMD. The findings of the trial sequential analysis revealed that adequate evidence has been obtained. The analysis of IL levels in adults and children with OSA compared with those without OSA revealed significant differences. In adults, IL-6 and IL-18 levels were significantly higher in the OSA group, while in children, only IL-6 and IL-23 levels were significantly elevated.</p>\",\"PeriodicalId\":16261,\"journal\":{\"name\":\"Journal of Interferon and Cytokine Research\",\"volume\":\" \",\"pages\":\"300-315\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2024-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Interferon and Cytokine Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1089/jir.2024.0057\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/5/17 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Interferon and Cytokine Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1089/jir.2024.0057","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/5/17 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
阻塞性睡眠呼吸暂停(OSA)是一种慢性炎症性疾病,其特点是睡眠时上气道部分或完全阻塞。我们的目的是通过系统综述荟萃分析评估几种细胞因子(白细胞介素 [IL]-6、IL-12、IL-17、IL-18 和 IL-23)的血清/血浆水平,将成人和儿童 OSA 患者与对照组进行比较。截至 2023 年 10 月 19 日,我们对 4 个数字数据库(PubMed、Web of Science、Scopus 和 Cochrane Library)进行了全面检索,没有任何限制。在进行荟萃分析时,我们使用了5.3版的Review Manager,并将数据显示为标准化平均差(SMD)和95%置信区间(CI),以评估细胞因子水平与OSA之间的相关性。我们使用 Comprehensive Meta-Analysis 3.0 版软件进行了偏倚分析、元回归和敏感性分析。在1881条记录中,有84篇文章被纳入系统综述和荟萃分析。在成人中,IL-6水平的集合SMD为0.79(P值<0.00001),IL-17水平的集合SMD为0.74(P值=0.14),IL-18水平的集合SMD为0.43(P值=0.00002)。在儿童中,IL-6的集合SMD为1.10(P值<0.00001),IL-12为0.47(P值=0.10),IL-17为2.21(P值=0.24),IL-18为0.19(P值=0.07),IL-23为2.46(P值<0.0001)。亚组分析表明,成人IL-6水平的种族、平均体重指数和平均呼吸暂停-低通气指数以及儿童IL-6水平的种族是影响集合SMD的有效因素。试验序列分析结果显示,已获得了充分的证据。对患有 OSA 的成人和儿童的 IL 水平与未患有 OSA 的成人和儿童的 IL 水平进行的分析表明,两者之间存在显著差异。在成人中,OSA组的IL-6和IL-18水平显著升高,而在儿童中,只有IL-6和IL-23水平显著升高。
Evaluation of Serum/Plasma Levels of Interleukins (IL-6, IL-12, IL-17, IL-18, and IL-23) in Adults and Children with Obstructive Sleep Apnea: A Systematic Review, Meta-Analysis, and Trial Sequential Analysis.
Obstructive sleep apnea (OSA) is a chronic inflammatory disease characterized by partial or complete upper airway obstruction during sleep. We aimed to evaluate serum/plasma levels of several cytokines (interleukin [IL]-6, IL-12, IL-17, IL-18, and IL-23) in a systematic review meta-analysis in both adults and children with OSA compared with controls. We conducted a comprehensive search of 4 digital databases (PubMed, Web of Science, Scopus, and Cochrane Library) up until October 19, 2023, without any limitations. For our meta-analysis, we used Review Manager, version 5.3, and displayed the data as the standardized mean difference (SMD) and 95% confidence interval (CI) to assess the correlation between cytokine levels and OSA. We utilized Comprehensive Meta-Analysis version 3.0 software to conduct bias analyses, meta-regression, and sensitivity analyses. From 1881 records, 84 articles were included in the systematic review and meta-analysis. In adults, the pooled SMDs for IL-6 level were 0.79 (P value < 0.00001), for IL-17 level were 0.74 (P value = 0.14), and for IL-18 level were 0.43 (P value = 0.00002). In children, the pooled SMD for IL-6 was 1.10 (P value < 0.00001), for IL-12 was 0.47 (P value = 0.10), for IL-17 was 2.21 (a P value = 0.24), for IL-18 was 0.19 (P value = 0.07), and for IL-23 was 2.46 (P value < 0.0001). The subgroup analysis showed that the ethnicity, mean body mass index, and mean apnea-hypopnea index for IL-6 levels in adults and the ethnicity for IL-6 levels in children were effective factors in the pooled SMD. The findings of the trial sequential analysis revealed that adequate evidence has been obtained. The analysis of IL levels in adults and children with OSA compared with those without OSA revealed significant differences. In adults, IL-6 and IL-18 levels were significantly higher in the OSA group, while in children, only IL-6 and IL-23 levels were significantly elevated.
期刊介绍:
Journal of Interferon & Cytokine Research (JICR) provides the latest groundbreaking research on all aspects of IFNs and cytokines. The Journal delivers current findings on emerging topics in this niche community, including the role of IFNs in the therapy of diseases such as multiple sclerosis, the understanding of the third class of IFNs, and the identification and function of IFN-inducible genes.