Jeffrey S. Richards, José A. Rosales, Saideh S. Mortazavi and James M. Salvador*,
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Small-Scale Synthesis of Dibenzyl Ketone for the Organic Chemistry Teaching Laboratory
Due to safety concerns, a larger scale synthesis (0.5 mol) of dibenzyl ketone (1,3-diphenylpropanone, DBK) was performed for more than ten years as a class wide demonstration in the second-semester undergraduate organic chemistry teaching laboratories at the University of Texas at El Paso. This synthetic step was added to a seven-step convergent synthesis of hexaphenylbenzene found in Experimental Organic Chemistry: A Small-Scale Approach, 2nd ed. by Wilcox and Wilcox. Herein, we report a safer, small-scale (7 mmol) synthesis and purification of DBK which allows students to perform the experiment individually or in pairs. In addition, because the iron byproducts generated proved difficult to remove from used glassware, a cleaning protocol using concentrated black tea was also developed.
期刊介绍:
The Journal of Chemical Education is the official journal of the Division of Chemical Education of the American Chemical Society, co-published with the American Chemical Society Publications Division. Launched in 1924, the Journal of Chemical Education is the world’s premier chemical education journal. The Journal publishes peer-reviewed articles and related information as a resource to those in the field of chemical education and to those institutions that serve them. JCE typically addresses chemical content, activities, laboratory experiments, instructional methods, and pedagogies. The Journal serves as a means of communication among people across the world who are interested in the teaching and learning of chemistry. This includes instructors of chemistry from middle school through graduate school, professional staff who support these teaching activities, as well as some scientists in commerce, industry, and government.