利用含羞草进行植物化学研究、抗蠕虫潜力评估和乳腺癌硅学筛选

Aravinth Velmurugan, Keerthana Chandramohan, Ganeshan Thamizhselvan, Yogesh Shokkalingam, Venkatesan Natarajan, Pradeepraj Devarasu, Thamizh Sendhamaraikannan
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引用次数: 0

摘要

在印度,乳腺癌是一个主要的健康问题,由于雌激素受体α和其他受体之间的相互作用经常导致细胞无节制地增殖和转移,乳腺癌对妇女的致死率很高。合成杀虫剂虽然效果良好,但对人类和动物的健康都有危害。因此,从植物中提取有效而安全的驱虫药是我们的主要目标。我们使用索氏提取系统用乙醇提取含羞草叶,浓缩后使用气相色谱-质谱、傅立叶变换红外光谱和紫外光谱技术检测提取物。我们使用 PubChem 和蛋白质数据库中的雌激素受体结构和黄酮类化合物数据库,分别对乳腺癌和驱虫作用进行了硅学测试。 通过分子对接和药物相似性研究,评估了天然化合物对乳腺癌的疗效。
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Phytochemical Study, Evaluation of Antihelminthic Potential and In silico Screening for Breast Cancer Using Mimosa pudica Linn.
Breast Cancer is a major health concern in India, where it is highly lethal for women because of unchecked cell proliferation and metastasis, which are frequently caused by interactions between the Estrogen Receptor Alpha and other receptors. Even though they work well, synthetic Anthelmintics come with dangers to the health of both humans and animals. Therefore, creating effective and safe Anthelmintics from plant sources is our main goal. We extracted Mimosa pudica leaves with ethanol using a Soxhlet system, and after concentration, we examined the extract using GC-MS, FTIR, and UV techniques. Estrogen Receptor structure and flavonoid compound databases from PubChem and Protein Data Bank were used for in silico testing against Breast Cancer and anthelmintic action, respectively.  Using molecular docking and drug similarity investigations, the effectiveness of natural compounds against Breast Cancer was evaluated.
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