与自身免疫性疾病风险等位基因相关的 lncRNA 的机制和功能。

3区医学 Q2 Medicine Advances in Immunology Pub Date : 2024-01-01 Epub Date: 2024-03-29 DOI:10.1016/bs.ai.2024.03.006

Ruxiao Tian, Sankar Ghosh

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引用次数: 0

摘要

人类基因组学技术的最新进展有助于发现许多复杂自身免疫性疾病的遗传风险等位基因。耐人寻味的是，超过 90% 的全基因组关联研究（GWAS）风险等位基因位于基因组的非编码区。新出现的功能和机理研究前沿揭示了长非编码 RNA（lncRNA）风险等位基因的功能相关性。在这里，我们回顾了五个进化保守的 lncRNA 的机制和功能意义，这些 lncRNA 显示出风险等位基因与高发自身免疫性疾病的关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Mechanisms and functions of lncRNAs linked to autoimmune disease risk alleles.

Recent advances in human genomics technologies have helped uncover genetic risk alleles for many complex autoimmune diseases. Intriguingly, over 90% of genome-wide association study (GWAS) risk alleles reside within the non-coding regions of the genome. An emerging new frontier of functional and mechanistic studies have shed light on the functional relevance of risk alleles that lie within long noncoding RNAs (lncRNAs). Here, we review the mechanisms and functional implications of five evolutionarily conserved lncRNAs that display risk allele association with highly prevalent autoimmune diseases.

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来源期刊

Advances in Immunology 医学-免疫学

CiteScore

9.90

自引率

0.00%

发文量

期刊介绍： Advances in Immunology has provided students and researchers with the latest information in Immunology for over 50 years. You can continue to rely on Advances in Immunology to provide you with critical reviews that examine subjects of vital importance to the field through summary and evaluation of current knowledge and research. The articles stress fundamental concepts, but also evaluate the experimental approaches.