Philippa Vaughn-Beaucaire, Moon Jung Choi, Olin Liang, Sean E Lawler
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Intracranial CAR-T cell delivery in glioblastoma patients.
Chimeric antigen receptor (CAR)-T cell therapy is emerging as a promising approach for improving outcomes in high-grade glioma. Here, we highlight three recent studies that reported safety and feasibility of intracranial CAR-T cell administration in patients with glioblastoma (GBM) as well as preliminary evidence of potential responses, supporting further investigations of this approach.
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