自制温阳健脾益气汤联合糠酸莫米松乳膏治疗脾虚湿聚型特应性皮炎的疗效及安全性研究

IF 1.6 4区 医学 Q3 OPHTHALMOLOGY Cutaneous and Ocular Toxicology Pub Date : 2024-09-01 Epub Date: 2024-05-23 DOI:10.1080/15569527.2024.2354734
Jinhui Tan, Yuting Fan, Luhui Liu, Lixia Deng, Xianzhou Li, Lifang Lan, Yuling Zeng
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引用次数: 0

摘要

引言本研究旨在探讨自制温阳健肤曲池汤加糠酸莫米松乳膏治疗脾虚湿聚型特应性皮炎(AD)的疗效和安全性。材料与方法将120例特应性皮炎患者分组:观察组(疾病健康教育+基础治疗+糠酸莫米松乳膏+自制煎剂)和对照组(疾病健康教育+基础治疗+糠酸莫米松乳膏)各60例。观察治疗后的 SCORAD 评分、血清 IgE 水平、外周血嗜酸性粒细胞、不良反应、复发率和总有效率:通过治疗,观察组的 SCORAD 评分(29.96 ± 2.88)低于对照组(36.04 ± 3.12),P 0.05。通过治疗,观察组外周血嗜酸性粒细胞计数为(311.26 ± 50.19)106/L,低于对照组(582.71 ± 54.75)106/L;观察组血清 lgE 为(712.44 ± 93.32)IU/mL,低于对照组(890.12 ± 81.25)IU/mL,P 0.05。观察组(56/60,93.33%)总有效率优于对照组(34/60,56.67%);观察组复发率为 4/60(6.67%),低于对照组 16/60(26.67%),P 0.05:自制温阳健脾益气汤加糠酸莫米松乳膏治疗脾虚湿聚型特应性皮炎疗效显著,安全性好。
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Efficacy and safety of self-made WenyangJianpi-qushi Decoction combined with mometasone furoate cream in the treatment of atopic dermatitis of spleen deficiency and dampness accumulation type.

Introduction: This work was to explore the efficacy and safety of self-made WenyangJianpi-qushi Decoction plus mometasone furoate cream in atopic dermatitis (AD) of spleen deficiency and dampness accumulation type. Material and method: 120 patients with this kind of atopic dermatitis were grouped: The Observation group (disease health education + basic treatment + mometasone furoate cream + self-made Decoction) and The Control group (disease health education + basic treatment + mometasone furoate cream), 60 cases in each group. The SCORAD score, serum IgE level, peripheral blood eosinophils, adverse events, recurrence rate, and total effective rate after treatment were observed.Result: Through treatment, SCORAD score of the observation group (29.96 ± 2.88) was lower as against controls (36.04 ± 3.12), p < 0.05. Through treatment, the peripheral blood eosinophil count in the observation group was (311.26 ± 50.19) 106/L, which was lower than (582.71 ± 54.75) 106/L in controls; the serum lgE of the observation group was (712.44 ± 93.32) IU/mL, which was lower than the controls (890.12 ± 81.25) IU/mL, p < 0.05. The Observation group (56/60, 93.33%) demonstrated superior total effective rate to the controls (34/60, 56.67%); The recurrence rate of the observation group was 4/60 (6.67%), which was lower than the controls 16/60 (26.67%), p < 0.05.Conclusion: Self-made WenyangJianpi-qushi Decoction plus mometasone furoate cream to treat atopic dermatitis of spleen deficiency and dampness accumulation type has significant efficacy and good safety.

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来源期刊
CiteScore
3.30
自引率
6.20%
发文量
40
审稿时长
1 months
期刊介绍: Cutaneous and Ocular Toxicology is an international, peer-reviewed journal that covers all types of harm to cutaneous and ocular systems. Areas of particular interest include pharmaceutical and medical products; consumer, personal care, and household products; and issues in environmental and occupational exposures. In addition to original research papers, reviews and short communications are invited, as well as concise, relevant, and critical reviews of topics of contemporary significance.
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