重症监护患者停止通气的比值评分:观察性研究方案

IF 2.3 Q3 BIOCHEMICAL RESEARCH METHODS Methods and Protocols Pub Date : 2024-05-20 DOI:10.3390/mps7030045
I. Cappellini, Andrea Cardoni, Lorenzo Campagnola, Guglielmo Consales
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引用次数: 0

摘要

背景:机械通气能明显提高患者的存活率,但也会带来并发症,增加医疗成本和发病率。要将这些风险降至最低,确定最佳断流时间至关重要,但目前的方法严重依赖临床判断,缺乏特异性。方法:本研究引入了一种新型多参数预测评分--MUSVIP(重症监护患者中断通气的多参数评分),旨在准确预测成功拔管的时间。这项单中心、观察性、前瞻性队列研究将在圣斯蒂法诺医院重症监护室进行,为期12个月,研究对象为接受有创机械通气的成年患者。MUSVIP 综合了自主呼吸试验 (SBT) 前和试验过程中测量的变量,以制定预测评分。研究结果初步分析表明,MUSVIP 的曲线下面积 (AUC) 为 0.815,显示出较高的预测能力。通过系统地应用该评分,我们预计能识别出更早成功断奶的患者,从而缩短重症监护室的住院时间并降低相关医疗费用。结论:这项研究的结果将对临床实践产生重大影响,为优化重症监护病房的断奶流程提供了一个强大、易用的工具。
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MUltiparametric Score for Ventilation Discontinuation in Intensive Care Patients: A Protocol for an Observational Study
Background: Mechanical ventilation significantly improves patient survival but is associated with complications, increasing healthcare costs and morbidity. Identifying optimal weaning times is paramount to minimize these risks, yet current methods rely heavily on clinical judgment, lacking specificity. Methods: This study introduces a novel multiparametric predictive score, the MUSVIP (MUltiparametric Score for Ventilation discontinuation in Intensive care Patients), aimed at accurately predicting successful extubation. Conducted at Santo Stefano Hospital’s ICU, this single-center, observational, prospective cohort study will span over 12 months, enrolling adult patients undergoing invasive mechanical ventilation. The MUSVIP integrates variables measured before and during a spontaneous breathing trial (SBT) to formulate a predictive score. Results: Preliminary analyses suggest an Area Under the Curve (AUC) of 0.815 for the MUSVIP, indicating high predictive capacity. By systematically applying this score, we anticipate identifying patients likely to succeed in weaning earlier, potentially reducing ICU length of stay and associated healthcare costs. Conclusion: This study’s findings could significantly influence clinical practices, offering a robust, easy-to-use tool for optimizing weaning processes in ICUs.
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来源期刊
Methods and Protocols
Methods and Protocols Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (miscellaneous)
CiteScore
3.60
自引率
0.00%
发文量
85
审稿时长
8 weeks
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