Squamous Cell Carcinoma of the Bladder: Two Case Report

Squamous cell carcinoma (SCC) of the bladder is a rare variant of bladder cancer, accounting for less than 5% of cases. Its occurrence shows a balanced distribution across sexes, although it tends to affect the Black population disproportionately. Clinical presentation is often nonspecific, with hematuria being the predominant symptom. Diagnosis relies on endoscopic resection of the bladder followed by histopathological examination. Due to its rarity, treatment approaches remain a subject of debate. However, radical cystectomy with extensive lymph node dissection is typically favored. In this study, we present a series comprising 2 cases of squamous cell carcinoma. Our objective is to shed light on the epidemiological, clinical, histopathological, and therapeutic aspects associated with squamous cell carcinoma of the bladder. The two cases presented in this study highlight the importance of accurate diagnosis and classification of squamous cell carcinoma of the bladder for optimal treatment planning and patient outcomes.