LncRNA MALAT1-miR-339-5p-NIS轴参与了高碘和高脂血症联合暴露诱导的促甲状腺激素(TSH)水平的升高。

IF 4.8 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Journal of Nutritional Biochemistry Pub Date : 2024-05-31 DOI:10.1016/j.jnutbio.2024.109672
Jinyin Yao , Chunpeng Lv , Peng Liu , Lijun Fan , Zhiwei Zhang , Yi Chen , Xianglan Chen , Xiaodan Zhang , Chunyu Zhang , Jinyu Li , Xuesong Wang , Wen Jiang , Jianxin Niu , Feng Song , Wei Zhang , Dianjun Sun
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引用次数: 0

摘要

甲状腺功能减退症和亚临床甲状腺功能减退症都以促甲状腺激素(TSH)水平升高为特征,以往的研究发现,单独的高碘或高脂血症与 TSH 水平有关。然而,它们对促甲状腺激素的联合影响尚未阐明。本研究通过对 Wistar 大鼠进行高碘水溶液和高脂饮食的联合暴露,确定了高碘和高脂血症的联合作用。结果表明,高碘和高脂的联合暴露可诱导促甲状腺激素水平升高。甲状腺组织中碘化钠转运体(NIS)和1型脱碘酶(D1)是合成甲状腺激素的关键基因,其mRNA和蛋白水平在联合暴露组明显下降。从机制上看,下调的lncRNA MALAT1可能通过增加miR-339-5p来调控NIS的表达,通过增加miR-224-5p来调控D1的表达。随后,研究人员在暴露于高碘水和高脂血症的受试者中对上述发现进行了探讨。结果表明,在合并高碘和高脂血症的人群中,TSH水平升高,lncRNA MALAT1-miR-339-5p-NIS轴明显被激活。综上所述,本研究发现,高碘和高脂血症联合暴露会诱导促甲状腺激素水平升高,而lncRNA MALAT1-miR-339-5p-NIS轴可能发挥了重要作用。
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LncRNA MALAT1-miR-339-5p-NIS axis is involved in the increased level of thyroid stimulating hormone (TSH) induced by combined exposure of high iodine and hyperlipidemia

Hypothyroidism and subclinical hypothyroidism were both characterized by elevated levels of thyroid stimulating hormone (TSH). Previous studies had found that high iodine or hyperlipidemia alone was associated with increased TSH level. However, their combined effects on TSH have not been elucidated. In this study, combination of high iodine and hyperlipidemia was established through the combined exposure of high-water iodine and high fat diet in Wistar rats. The results showed that combined exposure of high iodine and high fat can induce higher TSH level. The mRNA and protein levels of sodium iodide transporters (NIS) and type 1 deiodinase (D1) in thyroid tissues, which were crucial genes in the synthesis of thyroid hormones, decreased remarkably in combined exposure group. Mechanistically, down-regulated long non-coding RNA (lncRNA) metastasis associated in lung denocarcinoma transcript 1 (MALAT1) may regulate the expression of NIS by increasing miR-339-5p, and regulating D1 by increasing miR-224-5p. Then, the above findings were explored in subjects exposed to high water iodine and hyperlipidemia. The results indicated that in population combined with high iodine and hyperlipidemia, TSH level increased to higher level and lncRNA MALAT1-miR-339-5p-NIS axis was obviously activated. Collectively, this study found that combined exposure of high iodine and hyperlipidemia induced a higher level of TSH, and lncRNA MALAT1-miR-339-5p-NIS axis may play important role.

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来源期刊
Journal of Nutritional Biochemistry
Journal of Nutritional Biochemistry 医学-生化与分子生物学
CiteScore
9.50
自引率
3.60%
发文量
237
审稿时长
68 days
期刊介绍: Devoted to advancements in nutritional sciences, The Journal of Nutritional Biochemistry presents experimental nutrition research as it relates to: biochemistry, molecular biology, toxicology, or physiology. Rigorous reviews by an international editorial board of distinguished scientists ensure publication of the most current and key research being conducted in nutrition at the cellular, animal and human level. In addition to its monthly features of critical reviews and research articles, The Journal of Nutritional Biochemistry also periodically publishes emerging issues, experimental methods, and other types of articles.
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