{"title":"N6 腺苷 RNA 甲基化与 mRNA 剪接之间的相互作用","authors":"Majid Mehravar, Justin J-L Wong","doi":"10.1016/j.gde.2024.102211","DOIUrl":null,"url":null,"abstract":"<div><p><em>N</em><sup><em>6</em></sup>-methyladenosine (m<sup>6</sup>A) is the most abundant modification to mRNAs. Loss-of-function studies of main m<sup>6</sup>A regulators have indicated the role of m<sup>6</sup>A in pre-mRNA splicing. Recent studies have reported the role of splicing in preventing m<sup>6</sup>A deposition. Understanding the interplay between m<sup>6</sup>A and mRNA splicing holds the potential to clarify the significance of these fundamental molecular mechanisms in cell development and function, thereby shedding light on their involvement in the pathogenesis of myriad diseases.</p></div>","PeriodicalId":50606,"journal":{"name":"Current Opinion in Genetics & Development","volume":null,"pages":null},"PeriodicalIF":3.7000,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0959437X24000601/pdfft?md5=fd8e41b31a43b93bfe83fc06ed7cf249&pid=1-s2.0-S0959437X24000601-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Interplay between N6-adenosine RNA methylation and mRNA splicing\",\"authors\":\"Majid Mehravar, Justin J-L Wong\",\"doi\":\"10.1016/j.gde.2024.102211\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><em>N</em><sup><em>6</em></sup>-methyladenosine (m<sup>6</sup>A) is the most abundant modification to mRNAs. Loss-of-function studies of main m<sup>6</sup>A regulators have indicated the role of m<sup>6</sup>A in pre-mRNA splicing. Recent studies have reported the role of splicing in preventing m<sup>6</sup>A deposition. Understanding the interplay between m<sup>6</sup>A and mRNA splicing holds the potential to clarify the significance of these fundamental molecular mechanisms in cell development and function, thereby shedding light on their involvement in the pathogenesis of myriad diseases.</p></div>\",\"PeriodicalId\":50606,\"journal\":{\"name\":\"Current Opinion in Genetics & Development\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.7000,\"publicationDate\":\"2024-06-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S0959437X24000601/pdfft?md5=fd8e41b31a43b93bfe83fc06ed7cf249&pid=1-s2.0-S0959437X24000601-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Opinion in Genetics & Development\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0959437X24000601\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Genetics & Development","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0959437X24000601","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
Interplay between N6-adenosine RNA methylation and mRNA splicing
N6-methyladenosine (m6A) is the most abundant modification to mRNAs. Loss-of-function studies of main m6A regulators have indicated the role of m6A in pre-mRNA splicing. Recent studies have reported the role of splicing in preventing m6A deposition. Understanding the interplay between m6A and mRNA splicing holds the potential to clarify the significance of these fundamental molecular mechanisms in cell development and function, thereby shedding light on their involvement in the pathogenesis of myriad diseases.
期刊介绍：
Current Opinion in Genetics and Development aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed.
In Current Opinion in Genetics and Development we help the reader by providing in a systematic manner:
1. The views of experts on current advances in their field in a clear and readable form.
2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications.[...]
The subject of Genetics and Development is divided into six themed sections, each of which is reviewed once a year:
• Cancer Genomics
• Genome Architecture and Expression
• Molecular and genetic basis of disease
• Developmental mechanisms, patterning and evolution
• Cell reprogramming, regeneration and repair
• Genetics of Human Origin / Evolutionary genetics (alternate years)
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