肝脏虚弱指数:在所有实体器官移植中建立器官特异性虚弱指标的模型。

IF 1.8 4区 医学 Q3 TRANSPLANTATION Current Opinion in Organ Transplantation Pub Date : 2024-08-01 Epub Date: 2024-06-05 DOI:10.1097/MOT.0000000000001157
Gabrielle Jutras, Jennifer C Lai
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引用次数: 0

摘要

综述的目的:在这篇综述中,我们讨论了肝脏虚弱指数(LFI)的发展,以及如何将其作为发展其他器官特异性虚弱指数的模型:随着对实体器官移植的需求不断增加,移植界正在加强其器官分配策略,以便更深入地了解患者的风险状况和预期结果。虚弱已成为移植护理中的一个重要概念,它为了解不良健康结果提供了宝贵的信息。在移植项目中实现虚弱评估的标准化可以提高预后的准确性,并为移植前的干预措施提供依据。LFI由三个基于性能的测试组成,每个测试都代表了多维虚弱结构的重要组成部分。这一综合指标提供了肝功能以外的见解,并考虑了非肝合并症因素。在所有移植候选者中识别共同的虚弱原则并采用 LFI 方法(该方法使用肝脏特异性工具评估基本虚弱原则),可以建立一个共享核心虚弱原则的基础库。小结:在所有实体器官移植中建立一个标准化框架,采用共同的原则和器官特异性测量方法,将有助于进行一致的虚弱评估,将虚弱结构标准化地纳入移植决策,并使中心一级的干预措施能够改善终末期器官疾病患者的预后。
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The Liver Frailty Index: a model for establishing organ-specific frailty metrics across all solid organ transplantation.

Purpose of review: In this review, we discuss the development of the Liver Frailty Index (LFI) and how it may serve as a model for developing other organ-specific frailty indices.

Recent findings: As the demand for solid organ transplants continues to increase, the transplantation community is enhancing its strategies for organ allocation to gain deeper insights into patient risk profiles and anticipated outcomes. Frailty has emerged as a critical concept in transplant care, offering valuable insights into adverse health outcomes. Standardizing frailty assessment across transplant programs could enhance prognostic accuracy and inform pretransplant interventions.The LFI comprises of three performance-based tests that each represents essential components of the multidimensional frailty construct. This composite metric provides insights beyond liver function and considers nonhepatic comorbid factors. Identifying common frailty principles among all transplant candidates and adopting the LFI methodology, which assesses fundamental frailty principles using liver-specific tools, could establish a foundational pool of shared core frailty principles. From this pool, organ-specific frailty indices could be derived, each equipped with the clinically relevant organ-specific tools to evaluate common core principles.

Summary: Creating a standardized framework across all solid-organ transplants, with common principles and organ-specific measurements, would facilitate consistent frailty assessment, standardize the integration of the frailty construct into transplant decision-making, and enable center-level interventions to improve outcomes for patients with end-stage organ disease.

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来源期刊
CiteScore
4.10
自引率
4.50%
发文量
124
审稿时长
6-12 weeks
期刊介绍: ​​​​​​Current Opinion in Organ Transplantation is an indispensable resource featuring key, up-to-date and important advances in the field from around the world. Led by renowned guest editors for each section, every bimonthly issue of Current Opinion in Organ Transplantation delivers a fresh insight into topics such as stem cell transplantation, immunosuppression, tolerance induction and organ preservation and procurement. With 18 sections in total, the journal provides a convenient and thorough review of the field and will be of interest to researchers, surgeons and other healthcare professionals alike.
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