呋喃并噻二唑并吡嗪类固醇的合成及其抗增殖活性

IF 1.4 4区化学 Q3 CHEMISTRY, ORGANIC Chemistry of Heterocyclic Compounds Pub Date : 2024-06-03 DOI:10.1007/s10593-024-03319-x

Svetlana K. Vorontsova, Alexander M. Scherbakov, Mikhail E. Minyaev, Leonid G. Menchikov, Igor V. Zavarzin

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引用次数: 0

摘要

本研究开发了一种利用[1,2,5]噁二唑并[3,4-b]吡嗪和[1,2,5]噻二唑并[3,4-b]吡嗪片段合成杂环类固醇的有效方法。X 射线结构分析证实了这些产品的结构。所得化合物对乳腺癌（MCF7）和前列腺癌（22Rv1）细胞具有很高的抗增殖活性，其活性不低于顺铂和醋酸阿比特龙。

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The synthesis of furazano- and thiadiazolopyrazine steroids and their antiproliferative activity

An effective method for the synthesis of heterocyclic steroids with the [1,2,5]oxadiazolo[3,4-b]pyrazine and [1,2,5]thiadiazolo[3,4-b]-pyrazine fragments was developed. The structure of the products was confirmed by X-ray structural analysis. The resulting compounds showed high antiproliferative activity against breast (MCF7) and prostate (22Rv1) cancer cells, which was not inferior to that of cisplatin and abiraterone acetate.

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来源期刊

Chemistry of Heterocyclic Compounds 化学-有机化学

CiteScore

2.90

自引率

13.30%

发文量

审稿时长

1 months

期刊介绍： The international journal Chemistry of Heterocyclic Compounds publishes original papers, short communications, reviews, and mini-reviews dealing with problems in the field of heterocyclic chemistry in Russian and English. The Journal also publishes reviews and annotations on new books and brief reports on conferences in the field of heterocyclic chemistry, as well as commemoratives dedicated to prominent heterocyclic chemists.