黄酮类杂环衍生物的简易合成与应用。

IF 2.9 4区 医学 Q3 CHEMISTRY, MEDICINAL Current topics in medicinal chemistry Pub Date : 2024-06-05 DOI:10.2174/0115680266303704240524080333
Saba Farooq, Zainab Ngaini
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引用次数: 0

摘要

类黄酮属于多酚类化合物,天然存在于水果、蔬菜、茶叶和谷物中。类黄酮作为次生代谢产物,对生物化学过程和植物对多种环境因素的反应做出了不可或缺的贡献。类黄酮的生物活性取决于 C6-C3-C6 环的取代模式,它具有抗氧化、抗微生物、抗真菌、抗肿瘤和抗炎等生物活性。黄酮类化合物的合成方法多种多样。因此,本综述系统地总结了近期通过简便合成方法合成杂环类黄酮衍生物的情况,因为类黄酮的研究对治疗和生物技术领域非常有用。
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Facile Synthesis and Applications of Flavonoid-Heterocyclic Derivatives.

Flavonoids belong to the polyphenol group that naturally exists in fruits, vegetables, tea, and grains. Flavonoids, as secondary metabolites, show indispensable contributions to biolog-ical processes and the responses of plants to numerous environmental factors. The bioactivity of flavonoids depends on C6-C3-C6 ring substitution patterns that exhibit bioactive antioxidant, an-timicrobial, antifungal, antitumor, and anti-inflammatory properties. The synthesis of flavonoids has been reported by various methodologies. Therefore, the present review systematically sum-marizes the synthesis of recent heterocyclic flavonoid derivatives via facile synthetic approaches since the research in flavonoids is useful for therapeutic and biotechnology fields.

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来源期刊
CiteScore
6.40
自引率
2.90%
发文量
186
审稿时长
3-8 weeks
期刊介绍: Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.
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