病毒与宿主蛋白质相互作用的分子迷宫

IF 8.1 1区 医学 Q1 VIROLOGY Annual Review of Virology Pub Date : 2024-09-01 Epub Date: 2024-08-30 DOI:10.1146/annurev-virology-100422-034124
Maija E Pollari, William W E Aspelin, Linping Wang, Kristiina M Mäkinen
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引用次数: 0

摘要

壶菌病对农业的负面影响是广泛的、全球性的。了解蛋白质与蛋白质之间的相互作用如何导致壶状病毒感染,对于开发抗性品种以帮助应对壶状病毒带来的威胁至关重要。虽然有许多蛋白质-蛋白质相互作用的报道,但只有一小部分对壶状病毒感染至关重要。越来越多的证据表明,壶形病毒感染过程是相互关联的。例如,真核起始因子 4E(eIF4E)与病毒蛋白基因组连接蛋白(VPg)之间的相互作用对于病毒翻译和保护病毒 RNA(vRNA)至关重要。此外,最近有证据表明,反义 vRNA 上存在开放阅读框,病毒蛋白也存在非等摩尔表达,这对以前的多蛋白表达模型提出了挑战。这些发现必将揭示更多有关壶病毒蛋白质相互作用组的信息。在这篇综述中,我们对壶状病毒的感染周期进行了综述,并讨论了在各种感染过程中蛋白质-蛋白质相互作用方面过去有影响的发现和近期的工作。
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The Molecular Maze of Potyviral and Host Protein Interactions.

The negative effects of potyvirus diseases on the agricultural industry are extensive and global. Understanding how protein-protein interactions contribute to potyviral infections is imperative to developing resistant varieties that help counter the threat potyviruses pose. While many protein-protein interactions have been reported, only a fraction are essential for potyviral infection. Accumulating evidence demonstrates that potyviral infection processes are interconnected. For instance, the interaction between the eukaryotic initiation factor 4E (eIF4E) and viral protein genome-linked (VPg) is crucial for both viral translation and protecting viral RNA (vRNA). Additionally, recent evidence for open reading frames on the reverse-sense vRNA and for nonequimolar expression of viral proteins has challenged the previous polyprotein expression model. These discoveries will surely reveal more about the potyviral protein interactome. In this review, we present a synthesis of the potyviral infection cycle and discuss influential past discoveries and recent work on protein-protein interactions in various infection processes.

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来源期刊
CiteScore
19.40
自引率
0.90%
发文量
28
期刊介绍: The Annual Review of Virology serves as a conduit for disseminating thrilling advancements in our comprehension of viruses spanning animals, plants, bacteria, archaea, fungi, and protozoa. Its reviews illuminate novel concepts and trajectories in basic virology, elucidating viral disease mechanisms, exploring virus-host interactions, and scrutinizing cellular and immune responses to virus infection. These reviews underscore the exceptional capacity of viruses as potent probes for investigating cellular function.
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