HBO1,一种神秘的 KAT 及其与癌症的联系。

IF 2.6 3区 生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Biochimica et Biophysica Acta-Gene Regulatory Mechanisms Pub Date : 2024-06-06 DOI:10.1016/j.bbagrm.2024.195045
Akihiko Yokoyama , Hiroyuki Niida , Tatiana G. Kutateladze , Jacques Côté
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引用次数: 0

摘要

组蛋白乙酰转移酶 HBO1 又称 KAT7,是一种主要的染色质修饰酶,负责 H3 和 H4 乙酰化。它存在于两个不同的四聚体复合物(含 JADE 亚基的复合物和含 BRPF 亚基的复合物)中。HBO1-JADE 复合物对组蛋白 H4 的赖氨酸 5、8 和 12 进行乙酰化,而 HBO1-BRPF 复合物则对组蛋白 H3 的赖氨酸 14 进行乙酰化。HBO1 可调节基因转录、DNA 复制、DNA 损伤修复和中心粒功能。它参与多种信号通路,在发育和干细胞生物学中发挥着关键作用。最近的研究发现,HBO1 与急性髓性白血病中的组蛋白甲基转移酶 MLL/KMT2A 关系密切。在此,我们讨论了 HBO1 与癌症的功能和病理联系,强调了可能为开发新型抗癌疗法铺平道路的潜在机制。
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HBO1, a MYSTerious KAT and its links to cancer

The histone acetyltransferase HBO1, also known as KAT7, is a major chromatin modifying enzyme responsible for H3 and H4 acetylation. It is found within two distinct tetrameric complexes, the JADE subunit-containing complex and BRPF subunit-containing complex. The HBO1-JADE complex acetylates lysine 5, 8 and 12 of histone H4, and the HBO1-BRPF complex acetylates lysine 14 of histone H3. HBO1 regulates gene transcription, DNA replication, DNA damage repair, and centromere function. It is involved in diverse signaling pathways and plays crucial roles in development and stem cell biology. Recent work has established a strong relationship of HBO1 with the histone methyltransferase MLL/KMT2A in acute myeloid leukemia. Here, we discuss functional and pathological links of HBO1 to cancer, highlighting the underlying mechanisms that may pave the way to the development of novel anti-cancer therapies.

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来源期刊
CiteScore
9.20
自引率
2.10%
发文量
63
审稿时长
44 days
期刊介绍: BBA Gene Regulatory Mechanisms includes reports that describe novel insights into mechanisms of transcriptional, post-transcriptional and translational gene regulation. Special emphasis is placed on papers that identify epigenetic mechanisms of gene regulation, including chromatin, modification, and remodeling. This section also encompasses mechanistic studies of regulatory proteins and protein complexes; regulatory or mechanistic aspects of RNA processing; regulation of expression by small RNAs; genomic analysis of gene expression patterns; and modeling of gene regulatory pathways. Papers describing gene promoters, enhancers, silencers or other regulatory DNA regions must incorporate significant functions studies.
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