Sysmex XN-1000 血液分析仪报告的与中性粒细胞活化有关的扩展炎症参数对预测复杂性急性阑尾炎的有用性。与典型炎症实验室测试的比较

IF 1.3 4区 医学 Q3 SURGERY Cirugia Espanola Pub Date : 2024-06-01 DOI:10.1016/j.ciresp.2023.11.014
María Isabel Díaz López , Elena Crespo Álvarez , Álvaro Martínez Manzano , Eloísa Urrechaga , Manuel Tomás Orgaz Morales , Mercedes González Morales , Elena Martín García , Luis García de Guadiana-Romualdo
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引用次数: 0

摘要

目的准确诊断复杂性阑尾炎对确保患者及早接受有效治疗、最大限度降低术后并发症风险、促进患者顺利康复至关重要。生化指标是鉴别复杂性阑尾炎的有效工具。我们的目的是评估 Sysmex XN 系列分析仪报告的血细胞计数中包含的与中性粒细胞活化有关的新参数(称为 "扩展炎症参数"(EIP))与其他典型生物标记物相比在鉴别复杂性阑尾炎方面的潜在作用。手术前对 C 反应蛋白(CRP)、降钙素原、细胞计数(包括白细胞(WBC)、绝对中性粒细胞(ANC)和未成熟粒细胞(IG)计数)和 EIP(中性粒细胞反应性 [NEUT-RI] 和粒度强度 [NEUT-GI])进行分析。结果我们的研究共纳入 119 例患者,其中 58 例(48.7%)为复杂性阑尾炎。复杂性阑尾炎患者的 NLR、CRP 和降钙素原水平、ANC 和 IG 计数以及 NEUT-RI 和 NEUT-GI 均较高。就复杂性阑尾炎的准确性而言,CRP 是性能最高的生物标志物(ROC AUC:0.829),最佳临界值为 73.1 mg/L(灵敏度:63.8%,特异性:88.5%)。结论Sysmex XN 系列分析仪报告的新型实验室检测项目在鉴别复杂性阑尾炎方面的准确性较差。在这项研究中,CRP是性能最高的生物标志物,可用于预测急性阑尾炎的严重程度。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Usefulness of extended inflammatory parameters related to neutrophil activation reported by Sysmex XN-1000 hematology analyzer for predicting complicated acute appendicitis. Comparison with canonical inflammatory laboratory tests

Aim

Accurate diagnosis of complicated appendicitis is of importance to ensure that patients receive early and effective treatment, minimizing the risk of postoperative complications to promote successful recovery. Biochemical markers are a promising tool to identify complicated appendicitis. We aimed to evaluate the potential role of novel parameters related with neutrophil activation, known as “Extended Inflammation Parameters” (EIP), included in blood cell count reported by Sysmex XN-Series analyzers, compared to other canonical biomarkers in identifying complicated appendicitis.

Method

Prospective observational study including patients with confirmed diagnosis of acute appendicitis. C-reactive protein (CRP), procalcitonin, cell blood count, including white blood cell (WBC), absolute neutrophil (ANC) and immature granulocyte (IG) count and EIP (neutrophil reactivity [NEUT-RI] and granularity intensity [NEUT-GI]) were analyzed before surgery. Their accuracy to diagnose complicated appendicitis was tested in an ROC curve analysis.

Results

Our population study included 119 patients, and appendicitis was complicated in 58 (48.7%). NLR, CRP and procalcitonin levels, ANC and IG count and NEUT-RI and NEUT-GI were higher in patients with complicated appendicitis. Regarding accuracy for complicated appendicitis, CRP was the biomarker with the highest performance (ROC AUC: 0.829), with an optimal cutoff of 73.1 mg/L (sensitivity: 63.8%, specificity: 88.5%). NEUT-RI and NEUT-GI achieved both significant but poor accuracy, with ROC AUC of 0.606 and 0.637, respectively.

Conclusions

Novel laboratory tests reported by Sysmex XN-Series analyzers have poor accuracy for identifying complicated appendicitis. In this study, CRP was the biomarker with the highest performance and may be useful as predictor of the severity of acute appendicitis.

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来源期刊
Cirugia Espanola
Cirugia Espanola SURGERY-
CiteScore
1.20
自引率
21.10%
发文量
173
审稿时长
53 days
期刊介绍: Cirugía Española, an official body of the Asociación Española de Cirujanos (Spanish Association of Surgeons), will consider original articles, reviews, editorials, special articles, scientific letters, letters to the editor, and medical images for publication; all of these will be submitted to an anonymous external peer review process. There is also the possibility of accepting book reviews of recent publications related to General and Digestive Surgery.
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