常见和不常见的生长激素缺乏症小鼠模型。

IF 22 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM Endocrine reviews Pub Date : 2024-11-22 DOI:10.1210/endrev/bnae017
Edward O List, Reetobrata Basu, Darlene E Berryman, Silvana Duran-Ortiz, Gabriel Á Martos-Moreno, John J Kopchick
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引用次数: 0

摘要

生长激素缺乏症(GHD)小鼠模型为揭示 GH 的各种作用提供了重要工具。近 100 年来,利用这些小鼠品系进行的研究大大增进了我们对 GH/IGF-1 轴的了解。五种 "常见 "GHD小鼠模型的一些共同表型包括体型缩小、性成熟延迟、生育能力下降、肌肉质量减少、脂肪增加以及胰岛素敏感性增强。由于这些 "常见 "小鼠品系比正常体型的同系小鼠更长寿,而且不会患与年龄相关的疾病,因此它们已成为衰老领域的重要研究对象。另一方面,本文介绍的 12 种 "不常见 "GHD 小鼠模型的健康结果却大相径庭,既有有益的衰老表型(与常见模型类似),也有极为有害的特征(如中枢神经系统发育不良、多种感觉器官缺陷和胚胎致死)。此外,随着新一代测序技术的发展,越来越多的基因被确认为是多种伴有 GHD 的罕见综合征的致病因子。因此,本综述为研究人员提供了一个全面的最新GHD小鼠模型库,其中包括常见的和不常见的GHD小鼠模型,这些模型已被用于研究与多种GHD相关的生理和代谢的各个方面。对于介绍的每种小鼠品系,都讨论了与之最接近的人类综合征,为临床提供了重要的相似之处。
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Common and Uncommon Mouse Models of Growth Hormone Deficiency.

Mouse models of growth hormone deficiency (GHD) have provided important tools for uncovering the various actions of GH. Nearly 100 years of research using these mouse lines has greatly enhanced our knowledge of the GH/IGF-1 axis. Some of the shared phenotypes of the 5 "common" mouse models of GHD include reduced body size, delayed sexual maturation, decreased fertility, reduced muscle mass, increased adiposity, and enhanced insulin sensitivity. Since these common mouse lines outlive their normal-sized littermates-and have protection from age-associated disease-they have become important fixtures in the aging field. On the other hand, the 12 "uncommon" mouse models of GHD described herein have tremendously divergent health outcomes ranging from beneficial aging phenotypes (similar to those described for the common models) to extremely detrimental features (such as improper development of the central nervous system, numerous sensory organ defects, and embryonic lethality). Moreover, advancements in next-generation sequencing technologies have led to the identification of an expanding array of genes that are recognized as causative agents to numerous rare syndromes with concomitant GHD. Accordingly, this review provides researchers with a comprehensive up-to-date collection of the common and uncommon mouse models of GHD that have been used to study various aspects of physiology and metabolism associated with multiple forms of GHD. For each mouse line presented, the closest comparable human syndromes are discussed providing important parallels to the clinic.

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来源期刊
Endocrine reviews
Endocrine reviews 医学-内分泌学与代谢
CiteScore
42.00
自引率
1.00%
发文量
29
期刊介绍: Endocrine Reviews, published bimonthly, features concise timely reviews updating key mechanistic and clinical concepts, alongside comprehensive, authoritative articles covering both experimental and clinical endocrinology themes. The journal considers topics informing clinical practice based on emerging and established evidence from clinical research. It also reviews advances in endocrine science stemming from studies in cell biology, immunology, pharmacology, genetics, molecular biology, neuroscience, reproductive medicine, and pediatric endocrinology.
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