哒嗪酮类似物概述:化学和药理潜力。

IF 3.3 3区 医学 Q2 CHEMISTRY, MEDICINAL Mini reviews in medicinal chemistry Pub Date : 2024-06-07 DOI:10.2174/0113895575287746240528072330
Youness Boukharsa, Khalid Karrouchi, Houda Attjioui, Muhammed Ansar
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引用次数: 0

摘要

哒嗪酮是一种经典分子,在杂环化学中占有重要地位,自发现以来得到了广泛的发展。通过在哒嗪酮结构中引入新的官能团,可以合成多种多样的化合物。哒嗪酮衍生物在药理学和农用化学品方面的重要性引起了化学家们的兴趣,并将他们的研究方向引向了合成新化合物,以提高其生物有效性。在这篇综述中,我们汇编并讨论了哒嗪酮环的不同合成路线、反应活性以及药理和农用化学品应用。
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An Overview of Pyridazinone Analogs: Chemical and Pharmacological Potential.

Pyridazinones are classical molecules that occupy an important place in heterocyclic chemistry, and since their discovery, they have been widely developed. The introduction of new functional groups into pyridazinone structures has enabled the synthesis of a large diversity of compounds. The pharmacological and agrochemical importance of pyridazinone derivatives has aroused the interest of chemists and directed their research toward the synthesis of new compounds with the aim of improving their biological effectiveness. In this review, we have compiled and discussed the different synthetic routes, reactivity, and pharmacological and agrochemical applications of the pyridazinone ring.

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来源期刊
CiteScore
7.80
自引率
0.00%
发文量
231
审稿时长
6 months
期刊介绍: The aim of Mini-Reviews in Medicinal Chemistry is to publish short reviews on the important recent developments in medicinal chemistry and allied disciplines. Mini-Reviews in Medicinal Chemistry covers all areas of medicinal chemistry including developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies. Mini-Reviews in Medicinal Chemistry is an essential journal for every medicinal and pharmaceutical chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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