Janine Gellrich, Linda Czaplewski, Antje Hähner, Thomas Hummel
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引用次数: 0
摘要
简介:在 COVID-19 大流行期间,病毒后嗅觉功能障碍的发病率显著增加,给患者和从业人员带来了重大挑战。虽然嗅觉训练(OT)是一种常见的治疗方法,但人们对使用具有抗炎特性的棕榈酰乙醇酰胺(PEA)和木犀草素(LUT)组合进行辅助治疗的兴趣日益浓厚。本研究在一家门诊诊所调查了这两种药物对上呼吸道感染(主要是 COVID-19)后嗅觉丧失患者的治疗效果:方法:将 50 名持续性嗅觉功能障碍患者随机分为两组:一组接受 OT 和 PEA-LUT 治疗,另一组仅接受 OT 治疗。对治疗前后的嗅觉功能进行评估:结果:在接受 PEA-LUT 和 OT 治疗后,研究组患者的气味辨别能力和整体嗅觉功能(TDI 评分)均有明显改善,而对照组则没有。然而,如果考虑到有临床意义的改善,两组之间并无明显差异:本研究表明,虽然 PEA-LUT 有可能改善病毒后功能障碍患者的嗅觉功能,但与单独使用 OT 相比,其额外益处可能有限。这些结果与之前的一些研究形成了鲜明对比。
Palmitoylethanolamide and Luteolin for Postinfectious Olfactory Disorders: How Clinically Meaningful Is Its Effect?
Introduction: The prevalence of post-viral olfactory dysfunction has increased significantly during the COVID-19 pandemic, posing a major challenge for patients and practitioners. While olfactory training (OT) is a common approach to therapy, there has been increasing interest in supplementing therapy with a combination of palmitoylethanolamide (PEA) and luteolin (LUT), which are known for their anti-inflammatory properties. In this study, their efficacy in the treatment of patients with olfactory loss following upper respiratory tract infections, mainly COVID-19, was investigated in an outpatient clinic.
Methods: Fifty patients with persistent olfactory dysfunction were randomized to two groups: one receiving OT and PEA-LUT, the other OT alone. Olfactory function was evaluated before and after treatment.
Results: The study group showed significant improvements in odor discrimination and overall olfactory function (TDI score) after treatment with PEA-LUT and OT, while the control group did not. However, when clinically meaningful improvements were considered, there was no significant difference between the groups.
Conclusion: The present study suggests that while PEA-LUT may have the potential to improve olfactory function in post-viral dysfunction, the additional benefit over OT alone may be limited. These results contrast with some previous studies.
期刊介绍:
''ORL'' contains concise, original scientific papers of interest for both clinicians and researchers in oto-rhino-laryngology and head and neck surgery. Contributions drawn from the basic sciences cover new knowledge on the anatomy, pathology, pathophysiology, immunology and tumor biology of head and neck and the auditory and vestibular system, the salivary glands, paranasal sinuses and of the organs of the upper respiratory and digestive tract. The practical value of the journal is accentuated by reports of clinical progress in diagnosis and therapy.