涉及超重/肥胖儿童心血管健康和心率变异性的靶向蛋白质组学。

IF 1.6 4区医学 Q1 ANTHROPOLOGY American Journal of Human Biology Pub Date : 2024-06-12 DOI:10.1002/ajhb.24113

Abel Plaza-Florido, Marcos Olvera-Rojas, Juan M. A. Alcantara, Shlomit Radom-Aizik, Francisco B. Ortega

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引用次数: 0

摘要

背景：超重/肥胖儿童通常会表现出血浆蛋白谱的改变和心率变异性（HRV）的降低。血浆蛋白质组学在确定各种临床疾病的生物标志物方面处于领先地位。我们的目的是研究超重/肥胖症儿童中涉及心血管健康的血浆靶向蛋白质组学与静息迷走神经相关心率变异参数之间的关联：44名超重/肥胖症儿童（10.2 ± 1.1岁；52%为男孩）参加了研究。Olink技术用于量化92种与心血管健康有关的蛋白质。心率变异使用心率监测器（Polar RS800CX）进行测量。在时域和频域中得出了四个与静息迷走神经相关的心率变异参数：结果：八个蛋白质（KIM1、IgG Fc受体II-b、IDUA、BOC、IL1RL2、TNFRSF11A、VSIG2和TF）至少与四个迷走神经相关心率变异参数中的一个相关（β值从-0.188到0.288不等；均为P 0.05]）：血浆靶向蛋白质组学为超重/肥胖儿童的静息迷走神经相关心率变异参数提供了新的生物标志物。未来使用更大规模的队列和纵向设计进行的研究应能证实我们的发现及其潜在的临床意义。

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Targeted proteomics involved in cardiovascular health and heart rate variability in children with overweight/obesity

Background

Children with overweight/obesity often exhibit alterations in their plasma protein profiles and reduced heart rate variability (HRV). Plasma proteomics is at the forefront of identifying biomarkers for various clinical conditions. We aimed to examine the association between plasma-targeted proteomics involved in cardiovascular health and resting vagal-related HRV parameters in children with overweight/obesity.

Methods

Forty-four children with overweight/obesity (10.2 ± 1.1 years old; 52% boys) participated in the study. Olink's technology was used to quantify 92 proteins involved in cardiovascular health. HRV was measured using a heart rate monitor (Polar RS800CX). Four resting vagal-related HRV parameters were derived in time- and frequency-domain.

Results

Eight proteins (KIM1, IgG Fc receptor II-b, IDUA, BOC, IL1RL2, TNFRSF11A, VSIG2, and TF) were associated with at least one out of the four vagal-related HRV parameters (β values ranging from −0.188 to 0.288; all p < .05), while KIM1, IDUA, and BOC associated with ≥ three vagal-related HRV parameters. Multiple hypothesis testing corrections did not reach statistical significance (false discovery rate [FDR >0.05]).

Conclusion

Plasma-targeted proteomics suggested novel biomarkers for resting vagal-related HRV parameters in children with overweight/obesity. Future studies using larger cohorts and longitudinal designs should confirm our findings and their potential clinical implications.

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来源期刊

American Journal of Human Biology 生物-生物学

CiteScore

4.80

自引率

13.80%

发文量

124

审稿时长

4-8 weeks

期刊介绍： The American Journal of Human Biology is the Official Journal of the Human Biology Association. The American Journal of Human Biology is a bimonthly, peer-reviewed, internationally circulated journal that publishes reports of original research, theoretical articles and timely reviews, and brief communications in the interdisciplinary field of human biology. As the official journal of the Human Biology Association, the Journal also publishes abstracts of research presented at its annual scientific meeting and book reviews relevant to the field. The Journal seeks scholarly manuscripts that address all aspects of human biology, health, and disease, particularly those that stress comparative, developmental, ecological, or evolutionary perspectives. The transdisciplinary areas covered in the Journal include, but are not limited to, epidemiology, genetic variation, population biology and demography, physiology, anatomy, nutrition, growth and aging, physical performance, physical activity and fitness, ecology, and evolution, along with their interactions. The Journal publishes basic, applied, and methodologically oriented research from all areas, including measurement, analytical techniques and strategies, and computer applications in human biology. Like many other biologically oriented disciplines, the field of human biology has undergone considerable growth and diversification in recent years, and the expansion of the aims and scope of the Journal is a reflection of this growth and membership diversification. The Journal is committed to prompt review, and priority publication is given to manuscripts with novel or timely findings, and to manuscripts of unusual interest.