单细胞阴茎癌图谱确定疾病驱动因素

IF 12.1 1区医学 Q1 UROLOGY & NEPHROLOGY Nature Reviews Urology Pub Date : 2024-06-14 DOI:10.1038/s41585-024-00909-4

Maria Chiara Masone

引用次数: 0

摘要

阴茎鳞状细胞癌（PSCC）可分为人类乳头状瘤病毒阳性（HPV+）和HPV-独立型（HPV-）。与 HPV- 型肿瘤相比，HPV+ 型肿瘤的分化不良率更高。不过，据报道，HPV+患者的癌症特异性死亡率（CSM）低于HPV-患者。在发表于《欧洲泌尿学》（European Urology）的一项研究中，我们建立了一个 PSCC 单细胞 RNA 测序（scRNA-seq）图谱，以确定可能解释 HPV+ 和 HPV- 肿瘤患者预后差异的分子特征。研究人员对 16 例未经治疗的原发性 PSCC 患者的新鲜肿瘤样本和 6 例非恶性包皮内侧样本进行了 scRNA-seq 和 T 细胞受体测序。根据 HPV 和 TP53 状态共定义了四组：正常（n = 6）、HPV+ TP53 野生型（WT；n = 6）、HPV- TP53WT（n = 6）和 TP53LOF（无论 HPV 状态如何；n = 4）。对来自一个独立国际队列的患者进行的CSM分析验证了这些组别的预后相关性，TP53突变肿瘤患者的预后明显差于TP53WT肿瘤患者（P = 0.002）。scRNA-seq分析结果显示，TP53LOF肿瘤具有侵袭性表型，其特征是上皮细胞向间质转化、血管生成和免疫排斥的基因特征。HPV- TP53WT肿瘤表现出免疫衰竭，而HPV+ TP53WT肿瘤则表现出正常的上皮成熟和多个抗体-药物共轭靶点的上调，这表明其具有潜在的治疗作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Urology 医学-泌尿学与肾脏学

CiteScore

12.50

自引率

2.60%

发文量

123

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Urology is part of the Nature Reviews portfolio of journals.Nature Reviews' basic, translational and clinical content is written by internationally renowned basic and clinical academics and researchers. This journal targeted readers in the biological and medical sciences, from the postgraduate level upwards, aiming to be accessible to professionals in any biological or medical discipline. The journal features authoritative In-depth Reviews providing up-to-date information on topics within a field's history and development. Perspectives, News & Views articles, and the Research Highlights section offer topical discussions and opinions, filtering primary research from various medical journals. Covering a wide range of subjects, including andrology, urologic oncology, and imaging, Nature Reviews provides valuable insights for practitioners, researchers, and academics within urology and related fields.

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