非小细胞肺癌综述

Sunil Kumar Verma , Minakshi Pandey , Renu Khare , Devendra Singh
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引用次数: 0

摘要

肺癌是全球癌症死亡的主要原因之一,NSCLC(非小细胞肺癌)约占所有病例的 85%。NSCLC 具有复杂的遗传特征,多种驱动基因突变和表观遗传学改变会促进肿瘤进展和耐药性。NSCLC 可通过免疫疗法、化疗、放疗、手术或分子靶向疗法进行治疗。然而,大量接受过手术的患者很可能会出现局部复发或远处转移。最近几年,免疫疗法和靶向疗法发展迅速。在这篇综述中,我们将讨论非小细胞肺癌的相关细节、类型、预防措施和风险因素、症状、筛查方法、诊断和相关治疗,以及非小细胞肺癌的最新进展。
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A review on non-small cell lung cancer

Lung cancer is among the leading causes of death related to cancer globally, with NSCLC (non-small cell lung cancer) accounting for about 85% of all cases. NSCLC is characterized by a complex genetic landscape, with multiple driver mutations and epigenetic alterations that promote tumor progression and resistance to therapy. NSCLC is treated with immunotherapy, chemotherapy, radiation, surgery, or molecularly targeted therapy. However, a significant number of patients who had surgery are likely to experience local recurrence or distant metastases. Immunotherapy and targeted therapies have advanced rapidly in the last few years. Here, in this review, details related to NSCLC, its types, preventive measures, and risk factors, their symptoms, method of screening, diagnosis, and related treatment, and the latest updates related to NSCLC are discussed.

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