高通量筛选草履虫衰老生物标志物。

IF 3.8 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Biochemical Society transactions Pub Date : 2024-06-26 DOI:10.1042/BST20231303
Victoria R Yarmey, Adriana San-Miguel
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引用次数: 0

摘要

衰老的特点是,由于遗传和环境因素的复杂组合,机体的机能随着时间的推移而下降[ 1-4]。随着面临老年相关疾病风险的老年人口不断增加,迫切需要通过抗衰老干预措施来促进健康和长寿的研究。蛔虫秀丽隐杆线虫(Caenorhabditis elegans)因其生命周期短、易于培养和保守的衰老途径而成为衰老研究的成熟模式生物。这些优点也使该蠕虫非常适合采用高通量筛选(HTS)方法来研究与衰老相关的分子变化、细胞功能障碍和生理衰退的生物标志物。在这篇综述中,我们总结了用于研究优雅虫衰老生物标志物的 HTS 技术的最新进展。
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Biomarkers for aging in Caenorhabditis elegans high throughput screening.

Aging is characterized by a functional decline in organism fitness over time due to a complex combination of genetic and environmental factors [ 1-4]. With an increasing elderly population at risk of age-associated diseases, there is a pressing need for research dedicated to promoting health and longevity through anti-aging interventions. The roundworm Caenorhabditis elegans is an established model organism for aging studies due to its short life cycle, ease of culture, and conserved aging pathways. These benefits also make the worm well-suited for high-throughput screening (HTS) methods to study biomarkers of the molecular changes, cellular dysfunction, and physiological decline associated with aging. Within this review, we offer a summary of recent advances in HTS techniques to study biomarkers of aging in C. elegans.

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来源期刊
Biochemical Society transactions
Biochemical Society transactions 生物-生化与分子生物学
CiteScore
7.80
自引率
0.00%
发文量
351
审稿时长
3-6 weeks
期刊介绍: Biochemical Society Transactions is the reviews journal of the Biochemical Society. Publishing concise reviews written by experts in the field, providing a timely snapshot of the latest developments across all areas of the molecular and cellular biosciences. Elevating our authors’ ideas and expertise, each review includes a perspectives section where authors offer comment on the latest advances, a glimpse of future challenges and highlighting the importance of associated research areas in far broader contexts.
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