{"title":"颈动脉中的双相胆固醇平衡:血管假说","authors":"Nimai Chand Chandra , Varsha Suryan","doi":"10.1016/j.mehy.2024.111402","DOIUrl":null,"url":null,"abstract":"<div><p>Carotid artery intima media thickness (CIMT) is increased in cardiovascular (CRVD) and cerebrovascular diseases (CBVD) as well as in post cancer therapy. CIMT represents primarily the thickness of cholesterol on arterial wall. It gets increased in atherosclerotic impairment. A switch to hypocholesterolemia in the pathogenicity of carcinogenesis maintains CIMT at the thinner side. Cancer therapy increases the CIMT of carotid artery. Thus, CIMT may be used to differentiate the severity of atherosclerotic flare in post-cancer-therapy. We thus herein describe the diagnostic benefits of CIMT in the outcome of cardiovascular (CRVD), cerebrovascular (CBVD) and carcinogenesis type of disorders. We hypothesize that CIMT can be used as a common diagnostic index for joint venture viz the differentiation of atherosclerosis and carcinogenesis, both biochemically and clinically on a single template.</p></div>","PeriodicalId":18425,"journal":{"name":"Medical hypotheses","volume":"189 ","pages":"Article 111402"},"PeriodicalIF":2.1000,"publicationDate":"2024-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Biphasic cholesterol homeostasis in carotid artery: A vascular hypothesis\",\"authors\":\"Nimai Chand Chandra , Varsha Suryan\",\"doi\":\"10.1016/j.mehy.2024.111402\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Carotid artery intima media thickness (CIMT) is increased in cardiovascular (CRVD) and cerebrovascular diseases (CBVD) as well as in post cancer therapy. CIMT represents primarily the thickness of cholesterol on arterial wall. It gets increased in atherosclerotic impairment. A switch to hypocholesterolemia in the pathogenicity of carcinogenesis maintains CIMT at the thinner side. Cancer therapy increases the CIMT of carotid artery. Thus, CIMT may be used to differentiate the severity of atherosclerotic flare in post-cancer-therapy. We thus herein describe the diagnostic benefits of CIMT in the outcome of cardiovascular (CRVD), cerebrovascular (CBVD) and carcinogenesis type of disorders. We hypothesize that CIMT can be used as a common diagnostic index for joint venture viz the differentiation of atherosclerosis and carcinogenesis, both biochemically and clinically on a single template.</p></div>\",\"PeriodicalId\":18425,\"journal\":{\"name\":\"Medical hypotheses\",\"volume\":\"189 \",\"pages\":\"Article 111402\"},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2024-06-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Medical hypotheses\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0306987724001452\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medical hypotheses","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0306987724001452","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
Biphasic cholesterol homeostasis in carotid artery: A vascular hypothesis
Carotid artery intima media thickness (CIMT) is increased in cardiovascular (CRVD) and cerebrovascular diseases (CBVD) as well as in post cancer therapy. CIMT represents primarily the thickness of cholesterol on arterial wall. It gets increased in atherosclerotic impairment. A switch to hypocholesterolemia in the pathogenicity of carcinogenesis maintains CIMT at the thinner side. Cancer therapy increases the CIMT of carotid artery. Thus, CIMT may be used to differentiate the severity of atherosclerotic flare in post-cancer-therapy. We thus herein describe the diagnostic benefits of CIMT in the outcome of cardiovascular (CRVD), cerebrovascular (CBVD) and carcinogenesis type of disorders. We hypothesize that CIMT can be used as a common diagnostic index for joint venture viz the differentiation of atherosclerosis and carcinogenesis, both biochemically and clinically on a single template.
期刊介绍:
Medical Hypotheses is a forum for ideas in medicine and related biomedical sciences. It will publish interesting and important theoretical papers that foster the diversity and debate upon which the scientific process thrives. The Aims and Scope of Medical Hypotheses are no different now from what was proposed by the founder of the journal, the late Dr David Horrobin. In his introduction to the first issue of the Journal, he asks ''what sorts of papers will be published in Medical Hypotheses? and goes on to answer ''Medical Hypotheses will publish papers which describe theories, ideas which have a great deal of observational support and some hypotheses where experimental support is yet fragmentary''. (Horrobin DF, 1975 Ideas in Biomedical Science: Reasons for the foundation of Medical Hypotheses. Medical Hypotheses Volume 1, Issue 1, January-February 1975, Pages 1-2.). Medical Hypotheses was therefore launched, and still exists today, to give novel, radical new ideas and speculations in medicine open-minded consideration, opening the field to radical hypotheses which would be rejected by most conventional journals. Papers in Medical Hypotheses take a standard scientific form in terms of style, structure and referencing. The journal therefore constitutes a bridge between cutting-edge theory and the mainstream of medical and scientific communication, which ideas must eventually enter if they are to be critiqued and tested against observations.