重组蛋白在治疗类风湿关节炎中的作用

Q3 Biochemistry, Genetics and Molecular Biology Avicenna journal of medical biotechnology Pub Date : 2024-06-16 DOI:10.18502/ajmb.v16i3.15739
Mahboubeh Soleimani SasaniSasani, Yeganeh Moradi
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引用次数: 0

摘要

类风湿性关节炎(RA)是一种自身免疫性疾病和慢性炎症性疾病,会影响关节并引起炎症、疼痛、僵硬,最终导致关节进行性破坏。据估计,全球约有 1% 的人口患有类风湿性关节炎,如果不及时治疗,可能会导致严重残疾。尽管该领域的专业人士做出了种种努力并取得了进展,但目前还没有治疗RA的确切方法,大多数治疗策略旨在缓解症状和改善患者的生活质量。目前最有希望的方法之一是使用重组蛋白,这些蛋白可靶向参与RA发病的特定信号通路,从而缓解症状并延缓病情发展。本文讨论了影响RA发病的遗传和免疫因素、重组蛋白、使用这些蛋白的方法、已获批准的药物以及与治疗RA相关的副作用。
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Role of Recombinant Proteins for Treating Rheumatoid Arthritis
Rheumatoid Arthritis (RA) is an autoimmune disease and chronic inflammatory disorder that affects joints and causes inflammation, pain, stiffness, and eventually progressive joint destruction. Approximately 1% of the world's population is estimated to suffer from RA, and if this disease is left untreated, it can lead to severe disability. Despite all the efforts and advances made by professionals in the field, there is currently no definitive treatment for RA, and most treatment strategies are aimed at relieving symptoms and improving patients' quality of life. One of the most promising current approaches is the use of recombinant proteins that target specific signaling pathways involved in the development of RA to alleviate symptoms and slow the progression of the disease. This article discusses the genetic and immunological factors that influence the development of RA, recombinant proteins, methods of using these proteins, approved drugs, and side effects associated with treating RA.
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来源期刊
Avicenna journal of medical biotechnology
Avicenna journal of medical biotechnology Biochemistry, Genetics and Molecular Biology-Biotechnology
CiteScore
2.90
自引率
0.00%
发文量
43
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