对发现 GLP-1 作为饱腹感激素的思考：对肥胖症治疗的影响和未来方向。

IF 3.6 3区医学 Q2 NUTRITION & DIETETICS European Journal of Clinical Nutrition Pub Date : 2024-06-18 DOI:10.1038/s41430-024-01460-6

Arne Astrup

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引用次数: 0

摘要

科学家们一直在追寻一种增量素激素，当 GLP-1 最终被发现时，我们发现它具有明显的饱腹感，能减缓胃排空，实际上还能降低餐后胰岛素反应。这些机制是高效 GLP-1 类似物的基础，如今，这些类似物为数百万肥胖症患者提供了安全有效的治疗。此外，GLP-1 减少体重和延缓碳水化合物吸收的综合机制也可能是 GLP-1 类似物缓解 2 型糖尿病和减少心血管事件的关键因素。

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Reflections on the discovery GLP-1 as a satiety hormone: Implications for obesity therapy and future directions

Scientists were chasing an incretin hormone, and when GLP-1 was finally discovered, we found that it had a pronounced satiety effect, slowed down gastric emptying, and actually reduced postprandial insulin response. These mechanisms are the basis for the highly efficacious GLP-1 analogues that today offer safe and effective treatment in millions of people living with obesity. Moreover, the combined GLP-1 mechanisms of weight loss and delayed carbohydrate absorption may also be the key drivers of remission of type 2 diabetes and reduced cardiovascular events found by GLP-1 analogues.

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来源期刊

European Journal of Clinical Nutrition 医学-营养学

CiteScore

10.60

自引率

2.10%

发文量

189

审稿时长

3-6 weeks

期刊介绍： The European Journal of Clinical Nutrition (EJCN) is an international, peer-reviewed journal covering all aspects of human and clinical nutrition. The journal welcomes original research, reviews, case reports and brief communications based on clinical, metabolic and epidemiological studies that describe methodologies, mechanisms, associations and benefits of nutritional interventions for clinical disease and health promotion. Topics of interest include but are not limited to: Nutrition and Health (including climate and ecological aspects) Metabolism & Metabolomics Genomics and personalized strategies in nutrition Nutrition during the early life cycle Health issues and nutrition in the elderly Phenotyping in clinical nutrition Nutrition in acute and chronic diseases The double burden of ''malnutrition'': Under-nutrition and Obesity Prevention of Non Communicable Diseases (NCD)