Luís Cláudio Lima de Jesus , Rhayane Cristina Viegas Santos , Ludmila Silva Quaresma , Monique Ferrary Américo , Thaís Vilela Rodrigues , Andria dos Santos Freitas , Gabriela Munis Campos , Joyce da Cruz Ferraz Dutra , Fernanda Alvarenga Lima Barroso , Juliana Guimarães Laguna , Flávia Figueira Aburjaile , Philippe Langella , Jean-Marc Chatel , Vasco Azevedo
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引用次数: 0
摘要
背景德尔布鲁贝克乳杆菌(Lactobacillus delbrueckii)是一种用于乳制品工业的细菌,可改善乳制品的感官特性和营养价值。临床前研究已经证明了这些微生物的益生作用。然而,与其他乳酸菌种类不同的是,很少有研究采用益生基因组学方法探讨 L. delbrueckii 菌株对宿主健康的益处和安全性。此外,它还确定了通过益生基因组学方法获得的潜在遗传因素和分子机制,这些因素和机制可以帮助人们深入了解该物种对宿主健康的影响及其在生物技术和治疗应用方面的安全水平。主要发现和结论L. delbrueckii可以耐受工业和胃肠道压力,将这些微生物加入乳制品基质中可以增强这种特性。在肠道炎症、肠道感染、新陈代谢和心理失调等方面,已广泛证明了三角酵母的生物治疗活性。许多有益作用是由细菌细胞膜成分或分泌分子引起的,如细胞表面蛋白、外多糖、生物活性代谢物和肽。此外,在 L. delbrueckii 中发现的质粒很少,从而减少了抗生素耐药基因的传播。此外,该物种作为病原体的能力较低。然而,研究显示表型与基因型数据之间存在差异,这可能与基因表达水平或特定环境条件下的调控有关。因此,应开展进一步研究,以确定该物种可能的生物学作用,并确定与这些过程相关的遗传标记。
Health-promoting effects and safety aspects of Lactobacillus delbrueckii: A food industry species
Background
Lactobacillus delbrueckii is a bacterium used in the dairy industry, improving dairy products' organoleptic characteristics and nutritional value. Preclinical studies have demonstrated the probiotic effects of these microorganisms. However, unlike other lactic acid bacteria species, few studies have explored L. delbrueckii strains, using a probiogenomics approach, about their benefits and safety for host health.
Scope and approach
This comprehensive review describes the main health effects and safety features of L. delbrueckii strains. Furthermore, it also identifies potential genetic factors and molecular mechanisms obtained through the probiogenomics approach, which can offer insights into this species' effects on host health and its safety level for biotechnological and therapeutic applications.
Key findings and conclusions
L. delbrueckii can tolerate industrial and gastrointestinal stressors, and this property could be enhanced by incorporating these microorganisms into dairy matrices. The biotherapeutic activity of L. delbrueckii has been extensively demonstrated in intestinal inflammation, enteric infections, and metabolic and psychological disorders. Many beneficial effects are elicited by components of the bacteria cell membrane or secreted molecules, such as cell surface proteins, exopolysaccharides, bioactive metabolites, and peptides. Furthermore, few plasmids were identified in L. delbrueckii, reducing the spread of antibiotic-resistance genes. Additionally, this species has a lower capacity to act as a pathogen. However, studies show a discrepancy between the phenotype and genotype data, which may be related to the gene expression level or regulation in specific environmental conditions. Therefore, further studies should be conducted to characterize the possible biological role of this species and identify the genetic markers linked to these processes.
期刊介绍:
Trends in Food Science & Technology is a prestigious international journal that specializes in peer-reviewed articles covering the latest advancements in technology, food science, and human nutrition. It serves as a bridge between specialized primary journals and general trade magazines, providing readable and scientifically rigorous reviews and commentaries on current research developments and their potential applications in the food industry.
Unlike traditional journals, Trends in Food Science & Technology does not publish original research papers. Instead, it focuses on critical and comprehensive reviews to offer valuable insights for professionals in the field. By bringing together cutting-edge research and industry applications, this journal plays a vital role in disseminating knowledge and facilitating advancements in the food science and technology sector.