从马里牛身上采集的牛血吸虫和库拉索尼血吸虫的种群遗传结构。

IF 2.3 2区 医学 Q2 PARASITOLOGY Parasite Pub Date : 2024-01-01 Epub Date: 2024-07-02 DOI:10.1051/parasite/2024035
Assitan Diakité, Privat Agniwo, Abdoulaye Dabo, Bakary Sidibé, Boris A E S Savassi, Ahristode Akplogan, Hassim Guindo, Laurent Dembélé, Moudachirou Ibikounlé, Safiatou Doumbo Niaré, Saidou Tembely, Jérôme Boissier
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引用次数: 0

摘要

血吸虫病在医学和兽医学方面具有重要意义。尽管撒哈拉以南非洲地区的血吸虫病形势严峻,但很少开展分子流行病学研究来确定动物在血吸虫病传播中的作用。在马里,上一次对动物血吸虫进行分子研究已经是三十多年前的事了。现在迫切需要确定寄生虫的循环菌株,因为它们可能与其他血吸虫物种发生相互作用,这可能会使疾病控制工作复杂化。我们的工作旨在研究从牛身上采集的血吸虫种群的组成和遗传结构。血吸虫的流行率为 23.9%,其中牛血吸虫(Sb)和库拉索尼血吸虫(Sc)的流行率估计分别为 12.6% 和 9.8%。没有发现杂交株或血吸虫。寄生虫呈现出明显的地理分布特征,巴马科以 Sb 型寄生虫为主(在巴马科中央屠宰场和 Sabalibougou 屠宰场分别为 78.8% 和 98%),卡耶斯以 Sc 型寄生虫为主(95.3%)。在具有完整基因图谱的 476 只寄生虫中,60.4% 为纯 Sc 型寄生虫,主要来自卡耶斯。我们在地点水平上确定了两个群组(Sb 和 Sc 的 Fst 分别为 0.057 和 0.042)。聚类 1 主要由纯 Sb 寄生虫组成,聚类 2 主要由纯 Sc 寄生虫组成,分别来自巴马科和卡耶斯。我们的研究表明,在马里,牛血吸虫病仍然是由牛血吸虫(S. bovis)和库拉索尼血吸虫(S. curassoni)引起的地方病。研究发现,不同血吸虫种群之间存在稳固的遗传结构,其中包括基于寄生虫地理分布的两个群。
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Population genetic structure of Schistosoma bovis and S. curassoni collected from cattle in Mali.

Schistosomiasis is of medical and veterinary importance. Despite the critical situation of schistosomiasis in sub-Saharan Africa, few molecular epidemiological studies have been carried out to determine the role of animals in its transmission. In Mali, it has been over three decades since the last molecular study of animal schistosomes was carried out. It is now urgent to identify circulating strains of the parasite because of potential interactions with other schistosome species, which could complicate disease control. The aim of our work was to study the composition and genetic structure of schistosome populations collected from cattle. The prevalence of schistosome was 23.9%, with the prevalences of Schistosoma bovis (Sb) and S. curassoni (Sc) estimated at 12.6% and 9.8%, respectively. No hybrid strains or S. haematobium were found. The parasites displayed distinct geographical distribution with Sb dominant in Bamako (78.8% and 98% in Central Bamako Slaughterhouse and Sabalibougou Slaughterhouses, respectively) and Sc dominant in Kayes (95.3%). Of the 476 parasites with a complete genetic profile, 60.4% were pure Sc, and were mainly from Kayes. We identified two clusters at the site level (Fst of 0.057 and 0.042 for Sb and Sc, respectively). Cluster 1 was predominantly composed of pure Sb parasites and cluster 2 was mainly composed of pure Sc parasites, from Bamako and Kayes, respectively. Our study shows that cattle schistosomiasis remains endemic in Mali with S. bovis and S. curassoni. A robust genetic structure between the different schistosome populations was identified, which included two clusters based on the geographical distribution of the parasites.

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来源期刊
Parasite
Parasite 医学-寄生虫学
CiteScore
5.50
自引率
6.90%
发文量
49
审稿时长
3 months
期刊介绍: Parasite is an international open-access, peer-reviewed, online journal publishing high quality papers on all aspects of human and animal parasitology. Reviews, articles and short notes may be submitted. Fields include, but are not limited to: general, medical and veterinary parasitology; morphology, including ultrastructure; parasite systematics, including entomology, acarology, helminthology and protistology, and molecular analyses; molecular biology and biochemistry; immunology of parasitic diseases; host-parasite relationships; ecology and life history of parasites; epidemiology; therapeutics; new diagnostic tools. All papers in Parasite are published in English. Manuscripts should have a broad interest and must not have been published or submitted elsewhere. No limit is imposed on the length of manuscripts, but they should be concisely written. Papers of limited interest such as case reports, epidemiological studies in punctual areas, isolated new geographical records, and systematic descriptions of single species will generally not be accepted, but might be considered if the authors succeed in demonstrating their interest.
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