一例因筋膜内钙化骨化而发现的未分化脂肪肉瘤。

IF 0.5 Q4 ONCOLOGY International Cancer Conference Journal Pub Date : 2024-04-30 eCollection Date: 2024-07-01 DOI:10.1007/s13691-024-00682-6
Haruna Arai, Hirofumi Sogabe, Shinnosuke Morikawa, Osuke Arai, Ryuta Watanabe, Akira Ozawa, Akira I Hida, Tokuhiro Iseda, Kenichi Kohashi, Yoshinao Oda
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引用次数: 0

摘要

未分化脂肪肉瘤是一种罕见的癌症,预后较差。一名 52 岁的男子主诉左侧阴囊有肿块。他怀疑自己患了睾丸肿瘤,但所有测定的肿瘤标志物均为阴性。影像学检查显示,肿块直径约 2 厘米,伴有钙化,睾丸和附睾之间有一些实质性成分。患者接受了左侧高位睾丸切除术。肿瘤在睾丸和附睾之间没有连续性,精索横切术阴性。病理结果显示,小梁骨样组织周围有分化良好的脂肪成分和未分化成分。我们观察到去分化的畸形细胞与大小不等的脂肪滴混合在一起。免疫染色后诊断为脂肪肉瘤。术后没有进行额外的治疗。即使肿块局限在阴囊内且由钙化组成,也应牢记发生脂肪肉瘤的可能性。如果阴囊内的钙化肿块具有恶性特征,强烈建议进行根治性手术。
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A case of dedifferentiated liposarcoma discovered due to an intrascrotal calcified ossification.

Dedifferentiated liposarcoma is a rare cancer with a poor prognosis. A 52-year-old man presented with a chief complaint of a mass in his left scrotum. He came with suspected testicular tumor, but all the measured tumor markers were negative. Imaging test showed approximately 2 cm diameter mass accompanied by calcification with some substantial components between the testis and epididymis. Left high testicular resection was performed. The tumor had no continuity between the testis and epididymis, and the spermatic cord transection was negative. Pathological findings showed well differentiated fatty component and a dedifferentiated component around the trabecular bone-like tissue. We observed dedifferentiated dysmorphic cells mixed with fatty droplets of unequal size. Immunostaining led to the diagnosis of dedifferentiated liposarcoma. No additional postoperative therapy was performed. The possibility of dedifferentiated liposarcoma should be kept in mind even if mass is confined to the scrotum and consisted of calcification. In the case of an intrascrotal calcified mass with malignant perspective, radical surgery is highly recommended.

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来源期刊
自引率
14.30%
发文量
57
期刊介绍: This online-only journal publishes original case reports on all types of cancer. In particular, we welcome not only case reports of educational value in the diagnosis and treatment of cancers, but also reports on molecularly analyzed cancer cases, including gene mutations, gene fusions, gene expression, and changes in copy number, regardless of their known clinical significance. Assessing the molecular analysis of a tumor usually requires a “cancer conference” in which experts from various fields discuss it. Even if the authors and their respective “cancer conference” were unable to determine the clinical significance of molecular changes at the time of submission and publication, their data may provide evidence that will help the scientific community develop precision medicine solutions in the future. We welcome case reports with reviews of the literature on similar cases, as they are more useful and valuable to readers than are reports of rare cases. International Cancer Conference Journal is the official publication of the Japan Society of Clinical Oncology (JSCO). - Presents an online-only collection of original case reports on all types of cancer - In particular, welcomes molecularly analyzed cancer cases - The Official Publication of the Japan Society of Clinical Oncology (JSCO)
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