洞察新出现的 HER2 低度乳腺癌实体。

IF 1.6 Q4 ONCOLOGY International Journal of Breast Cancer Pub Date : 2024-06-13 eCollection Date: 2024-01-01 DOI:10.1155/2024/2853007
Georges El Haddad, Ernest Diab, Michel Hajjar, Maroun Aoun, Farid Mallat, Ziad Zalaquett, Hampig-Raphael Kourie
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引用次数: 0

摘要

人表皮生长因子受体 2(HER2)低表达乳腺癌(BC)是最近被认为是一种独立临床实体的 BC 亚型,具有不同的临床和分子特征。它的定义是 HER2 蛋白表达水平低,这使其有别于其他更具侵袭性的 BC 亚型。早期研究表明,它的预后可能比 HER2 阳性 BC 更好,因为它较少扩散到身体的其他部位,对化疗、放疗和激素治疗等标准 BC 治疗的反应可能更强。鉴于 HER2 低度 BC 的出现相对较晚,人们对这一亚型仍有很多需要了解的地方;目前的研究重点是确定导致 HER2 低度 BC 的潜在基因突变,以及开发可改善该病患者预后的靶向疗法。本综述旨在总结目前有关 HER2 低水平 BC 的临床知识,目的是更好地了解这一实体,为潜在的干预措施和新的治疗标准铺平道路。
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Insights Into the Emerging Entity of HER2-Low Breast Cancer.

Human epidermal growth factor receptor 2 (HER2)-low breast cancer (BC) is a subtype of BC that has been recently recognized as a separate clinical entity with distinct clinical and molecular characteristics. It is defined by a low level of HER2 protein expression, which distinguishes it from other more aggressive BC subtypes. Early studies suggest that it may have a more favorable prognosis than HER2-positive BC, as it is less likely to spread to other parts of the body and may be more responsive to standard BC treatments such as chemotherapy, radiation therapy, and hormone therapy. Given the relative new emergence of HER2-low BC, there is still much to be learned about this subtype; ongoing research is focused on identifying the underlying genetic mutations that contribute to HER2-low BC as well as developing targeted therapies that can improve outcomes for patients with this disease. This review is aimed at summarizing the current clinical knowledge on HER2-low BC, with the aim of creating a better understanding of this entity and paving the way for potential interventions and a new standard of care.

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来源期刊
CiteScore
3.40
自引率
0.00%
发文量
25
审稿时长
19 weeks
期刊介绍: International Journal of Breast Cancer is a peer-reviewed, Open Access journal that provides a forum for scientists, clinicians, and health care professionals working in breast cancer research and management. The journal publishes original research articles, review articles, and clinical studies related to molecular pathology, genomics, genetic predisposition, screening and diagnosis, disease markers, drug sensitivity and resistance, as well as novel therapies, with a specific focus on molecular targeted agents and immune therapies.
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