Kazuki Hori, Shunsuke Onuma, Yuta Nakazato, Tomoya Mashiko, Akihiko Kasamatsu, Akinobu Matsuzawa, Shogo Kamo, Kazuyuki Sugita
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引用次数: 0
摘要
本文介绍了珊瑚苣苔素 B 和 C 的首次全合成。Suzukii-Miyaura 偶联是完成合成的关键。据报道，这两种天然产物可诱导人类星形胶质细胞中神经营养素的表达，因此有望成为治疗神经退行性疾病的新药线索。
Total syntheses of fungal isoindolinones corallocins B and C
The first total syntheses of corallocins B and C are described herein. The Suzuki–Miyaura coupling was key to completion. Because these two natural products have been reported to induce neurotrophin expression in human astrocytes, they are expected to serve as new drug leads for neurodegenerative diseases.
期刊介绍：
The Journal of Heterocyclic Chemistry is interested in publishing research on all aspects of heterocyclic chemistry, especially development and application of efficient synthetic methodologies and strategies for the synthesis of various heterocyclic compounds. In addition, Journal of Heterocyclic Chemistry promotes research in other areas that contribute to heterocyclic synthesis/application, such as synthesis design, reaction techniques, flow chemistry and continuous processing, multiphase catalysis, green chemistry, catalyst immobilization and recycling.
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