年轻人早期结肠癌

IF 1.2 4区 医学 Q4 GASTROENTEROLOGY & HEPATOLOGY Clinics in Colon and Rectal Surgery Pub Date : 2024-07-02 DOI:10.1055/s-0044-1787883
David Cohen, Caitlin Rogers, Joel Gabre, Beatrice Dionigi
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引用次数: 0

摘要

早发结直肠癌(EO-CRC)的特点是在 50 岁之前确诊,随着全球发病率的不断上升,它已成为一项重大的医疗挑战。虽然家族史和遗传综合征等传统风险因素是导致 EO-CRC 的原因之一,但相当一部分病例仍为散发性,因此有必要进一步研究其他病因。分子研究揭示了 EO-CRC 的异质性,与晚发性 CRC 相比,EO-CRC 具有不同的突变特征。临床管理需要考虑一些独特的因素,包括早期检测的挑战和针对年轻患者的治疗策略。应对 EO-CRC 需要多学科方法,整合流行病学、分子学和临床见解,以改善预防、诊断和治疗效果。新出现的研究途径探索了新型生物标记物和治疗靶点,为在当代肿瘤学实践中促进对这种疾病的理解和管理提供了希望。
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The Young: Early-Onset Colon Cancer

Early-onset colorectal cancer (EO-CRC), characterized by diagnosis before the age of 50 years, has emerged as a significant healthcare challenge with increasing global incidence. While traditional risk factors such as family history and inherited syndromes contribute to EO-CRC, a substantial proportion of cases remain sporadic, necessitating further investigation into additional etiological factors. Molecular studies reveal heterogeneity in EO-CRC, with distinct mutational profiles compared to late-onset CRC. Clinical management presents unique considerations, including challenges in early detection and treatment strategies tailored to younger patients. Addressing EO-CRC requires a multidisciplinary approach integrating epidemiological, molecular, and clinical insights to improve prevention, diagnosis, and therapeutic outcomes. Emerging research avenues explore novel biomarkers and therapeutic targets, offering promise for advancing understanding and management of this disease in contemporary oncology practice.

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来源期刊
Clinics in Colon and Rectal Surgery
Clinics in Colon and Rectal Surgery GASTROENTEROLOGY & HEPATOLOGYSURGERY-SURGERY
CiteScore
2.60
自引率
7.10%
发文量
84
期刊介绍: Clinics in Colon and Rectal Surgery is a review journal that publishes topic-specific issues on diseases of the small bowel, colon, rectum, and anus. Designed for clinicians, researchers, and educators involved with diseases of the intestinal tract, the journal covers a broad spectrum of basic information, controversial clinical issues, and established and innovative diagnostic techniques. Issue topics comprehensively cover the entire specialty over a 3-4 year period, allowing the articles to serve as study material for educational programs and certifying examinations. The inclusion of research and clinical material also allows physicians to remain knowledgeable of current advances in the specialty.
期刊最新文献
Corrigendum: Current Position of Sacral Neuromodulation in Treatment of Fecal Incontinence. Current Trends in the Management of a Complex Polyp: Endoscopy versus Surgery Hereditary Colorectal Cancer: From Diagnosis to Surgical Options The Young: Early-Onset Colon Cancer The Old: Is There Any Role for Screening Colonoscopy after the Age of 75? The Surgeon's Perspective
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