使用吉布斯试剂分光光度法测定肾上腺素、盐酸肾上腺素和硫酸特布他林

IF 1 4区 化学 Q4 CHEMISTRY, ANALYTICAL Journal of Analytical Chemistry Pub Date : 2024-06-21 DOI:10.1134/s1061934824700163
Asmaa H. Abbas, Theia’a N. Al-Sabha, Subhi M. J. Al-Mtwaiti
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引用次数: 0

摘要

摘要 已开发出一种分光光度法,用于测定某些含胺酚的药物,即肾上腺素、盐酸肾上腺素和硫酸特布他林。该方法依赖于药物在 pH 值为 11 的碱性硼酸盐缓冲介质中与吉布斯试剂(2,6-二氯醌-4-氯酰胺)反应生成的新产物。在 0.3-9.5、0.5-17 和 0.5-55 µg/mL 范围内符合比尔-朗伯定律,平均回收率分别为 101.10%、99.13%和 99.78%,相对标准偏差≤3.31%。该方法不受辅料干扰,可成功用于所研究药物的药物制剂检测。所得产物的比例为 1:1。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Spectrophotometric Determination of Adrenaline, Phenylephrine Hydrochloride, and Terbutaline Sulfate Using the Gibbs Reagent

Abstract

A spectrophotometric method has been developed for the determination of certain amine-phenol-containing drugs, namely, adrenaline, phenylephrine hydrochloride, and terbutaline sulfate. The method depends on the formation of new products by the reaction of drugs with the Gibbs reagent (2,6-dichloroquinone-4-chloroamide) in a basic borate buffer medium with a pH value of 11. The products were measured at 475, 652.5, and 547 nm for the aforementioned drugs, respectively. Beer–Lambert law was obeyed in the ranges of 0.3–9.5, 0.5–17, and 0.5–55 µg/mL with average recovery of 101.10, 99.13, and 99.78% and a relative standard deviation of ≤3.31%, respectively. The method was free from excipient interferences and applied successfully for the assay of the studied drugs in their pharmaceutical formulations. The resulting products were found in the ratio of 1 : 1.

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来源期刊
Journal of Analytical Chemistry
Journal of Analytical Chemistry 化学-分析化学
CiteScore
2.10
自引率
9.10%
发文量
146
审稿时长
13 months
期刊介绍: The Journal of Analytical Chemistry is an international peer reviewed journal that covers theoretical and applied aspects of analytical chemistry; it informs the reader about new achievements in analytical methods, instruments and reagents. Ample space is devoted to problems arising in the analysis of vital media such as water and air. Consideration is given to the detection and determination of metal ions, anions, and various organic substances. The journal welcomes manuscripts from all countries in the English or Russian language.
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