HLA-B27相关前葡萄膜炎的脉络膜和视网膜血管变化。

IF 2.1 3区 医学 Q2 OPHTHALMOLOGY Japanese Journal of Ophthalmology Pub Date : 2024-09-01 Epub Date: 2024-07-05 DOI:10.1007/s10384-024-01080-4
Heejeong Chun, Joo Young Kim, Rae Young Kim, Mirinae Kim, Young-Gun Park, Young-Hoon Park
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引用次数: 0

摘要

目的:定量分析HLA-B27相关前葡萄膜炎的脉络膜和视网膜血管变化:方法:回顾性研究:方法:回顾性研究51例单侧HLA-B27相关性前葡萄膜炎患者及其同侧眼和47例性别与年龄匹配的健康眼的病历。使用扫源(SS)光学相干断层扫描(OCT)和OCT血管造影(OCTA)扫描分析了他们的脉络膜和视网膜血管:结果:深毛细血管丛(DCP)血管密度(VD)(p 结论:某些脉络膜和视网膜血管密度较低:某些脉络膜和视网膜血管参数在无后节受累的HLA-B27相关性前葡萄膜炎和安静的同侧眼中都发生了显著变化,这表明它们可能是一种全身性炎症性疾病。
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Choroidal and retinal vascular changes in HLA-B27-associated anterior uveitis.

Purpose: To quantitatively analyze choroidal and retinal vascular changes in HLA-B27-associated anterior uveitis.

Study design: A retrospective study.

Methods: Medical records of 51 eyes with unilateral HLA-B27-associated anterior uveitis, their fellow eyes and 47 sex and age-matched healthy eyes were retrospectively reviewed. Their choroidal and retinal vasculature were analyzed using swept-source (SS) optical coherence tomography (OCT) and OCT angiography (OCTA) scans.

Results: Deep capillary plexus (DCP) vessel density (VD) (p < 0.001), choroidal vascularity index (CVI) (p = 0.012), and choriocapillary flow deficit (CCFD) (p < 0.001) of uveitic and fellow eye group were significantly higher than those of control group. On the contrary, superficial capillary plexus (SCP) VD (p < 0.001) of uveitic and fellow eye group were significantly lower than of control group. The vascular parameters of uveitis and fellow eye group showed no significant difference between uveitic and resolution period.

Conclusion: Certain choroidal and retinal vascular parameters were significantly changed in both HLA-B27-associated anterior uveitis without posterior segment involvement and the quiet fellow eyes, suggesting their possible effects as a systemic inflammatory disorder.

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来源期刊
CiteScore
4.80
自引率
8.30%
发文量
65
审稿时长
6-12 weeks
期刊介绍: The Japanese Journal of Ophthalmology (JJO) was inaugurated in 1957 as a quarterly journal published in English by the Ophthalmology Department of the University of Tokyo, with the aim of disseminating the achievements of Japanese ophthalmologists worldwide. JJO remains the only Japanese ophthalmology journal published in English. In 1997, the Japanese Ophthalmological Society assumed the responsibility for publishing the Japanese Journal of Ophthalmology as its official English-language publication. Currently the journal is published bimonthly and accepts papers from authors worldwide. JJO has become an international interdisciplinary forum for the publication of basic science and clinical research papers.
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