Hayami K. Koga , Francine Grodstein , David R. Williams , Dawn L. Demeo , Laura D. Kubzansky
{"title":"乐观主义和人生目标与衰老过程中免疫指标的关系。","authors":"Hayami K. Koga , Francine Grodstein , David R. Williams , Dawn L. Demeo , Laura D. Kubzansky","doi":"10.1016/j.jpsychores.2024.111851","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>Optimism and purpose in life are associated with improved health outcomes. More information is needed on biological mechanisms, including immunosenescence. We investigated if psychological well-being is associated with healthier immunosenescence-related measures including naïve and terminally differentiated CD4<sup>+</sup> and CD8<sup>+</sup> T cell percentages, CD4<sup>+</sup>:CD8<sup>+</sup>, and cytomegalovirus (CMV) IgG response.</p></div><div><h3>Methods</h3><p>Participants were adults over age 50 from the Health and Retirement Study. Optimism was measured using the Life Orientation Test Revised. Purpose in life was assessed using the subscale from the Ryff psychological well-being measure. We examined the cross-sectional associations of optimism and purpose in life with measures of T cell subsets using linear regression and with CMV IgG using ordered logit regression, controlling for potential confounding factors.</p></div><div><h3>Results</h3><p>The final analytic sample ranged from 7250 to 7870. After adjusting for sociodemographic factors, a 1-SD increment in optimism was associated with the percentage of naïve CD4<sup>+</sup> T cells increasing by 0.6 (95%CI 0.2%, 1.0%). A 1-SD increment in purpose in life was associated with the percentage of naïve CD4<sup>+</sup> T cells increasing by 0.9 (95%CI 0.5%, 1.3%) after adjusting for sociodemographic factors and the association was maintained after further adjustments for health conditions, depression, and health behaviors. For naïve CD8<sup>+</sup> T cell percentages, CD4:CD8 ratios, and CMV IgG antibodies, associations were seen only in models that adjusted for age. No significant associations were seen in any models for the terminally differentiated CD4<sup>+</sup> and CD8<sup>+</sup> T cells.</p></div><div><h3>Conclusions</h3><p>We found associations of optimism and purpose in life with naïve CD4<sup>+</sup> T cell percentages.</p></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":null,"pages":null},"PeriodicalIF":3.5000,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Relations of optimism and purpose in life to immune markers in aging\",\"authors\":\"Hayami K. Koga , Francine Grodstein , David R. Williams , Dawn L. Demeo , Laura D. Kubzansky\",\"doi\":\"10.1016/j.jpsychores.2024.111851\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><p>Optimism and purpose in life are associated with improved health outcomes. More information is needed on biological mechanisms, including immunosenescence. We investigated if psychological well-being is associated with healthier immunosenescence-related measures including naïve and terminally differentiated CD4<sup>+</sup> and CD8<sup>+</sup> T cell percentages, CD4<sup>+</sup>:CD8<sup>+</sup>, and cytomegalovirus (CMV) IgG response.</p></div><div><h3>Methods</h3><p>Participants were adults over age 50 from the Health and Retirement Study. Optimism was measured using the Life Orientation Test Revised. Purpose in life was assessed using the subscale from the Ryff psychological well-being measure. We examined the cross-sectional associations of optimism and purpose in life with measures of T cell subsets using linear regression and with CMV IgG using ordered logit regression, controlling for potential confounding factors.</p></div><div><h3>Results</h3><p>The final analytic sample ranged from 7250 to 7870. After adjusting for sociodemographic factors, a 1-SD increment in optimism was associated with the percentage of naïve CD4<sup>+</sup> T cells increasing by 0.6 (95%CI 0.2%, 1.0%). A 1-SD increment in purpose in life was associated with the percentage of naïve CD4<sup>+</sup> T cells increasing by 0.9 (95%CI 0.5%, 1.3%) after adjusting for sociodemographic factors and the association was maintained after further adjustments for health conditions, depression, and health behaviors. For naïve CD8<sup>+</sup> T cell percentages, CD4:CD8 ratios, and CMV IgG antibodies, associations were seen only in models that adjusted for age. No significant associations were seen in any models for the terminally differentiated CD4<sup>+</sup> and CD8<sup>+</sup> T cells.</p></div><div><h3>Conclusions</h3><p>We found associations of optimism and purpose in life with naïve CD4<sup>+</sup> T cell percentages.</p></div>\",\"PeriodicalId\":50074,\"journal\":{\"name\":\"Journal of Psychosomatic Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.5000,\"publicationDate\":\"2024-06-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Psychosomatic Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0022399924002630\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PSYCHIATRY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Psychosomatic Research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0022399924002630","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PSYCHIATRY","Score":null,"Total":0}
引用次数: 0
摘要
目标乐观情绪和人生目标与健康状况的改善有关。我们需要更多有关生物机制的信息,包括免疫衰老。我们研究了心理健康是否与更健康的免疫衰老相关指标(包括幼稚和终末分化的 CD4+ 和 CD8+ T 细胞百分比、CD4+:CD8+ 和巨细胞病毒 (CMV) IgG 反应)有关:参与者为健康与退休研究(Health and Retirement Study)中 50 岁以上的成年人。乐观程度通过生活取向测试修订版进行测量。生活目的采用 Ryff 心理幸福感量表的子量表进行评估。我们使用线性回归方法研究了乐观情绪和生活目的与 T 细胞亚群测量的横截面关联,并使用有序对数回归方法研究了乐观情绪和 CMV IgG 与 T 细胞亚群测量的横截面关联,同时控制了潜在的混杂因素:最终分析样本为 7250 至 7870 人。在对社会人口因素进行调整后,乐观程度每增加 1 个标准差,幼稚 CD4+ T 细胞的百分比就会增加 0.6(95%CI 0.2%,1.0%)。在对社会人口因素进行调整后,生活目标增加 1 个标准差与幼稚 CD4+ T 细胞百分比增加 0.9(95%CI 0.5%,1.3%)有关,在对健康状况、抑郁和健康行为进行进一步调整后,这种关联得以保持。就幼稚 CD8+ T 细胞百分比、CD4:CD8 比率和 CMV IgG 抗体而言,只有在调整了年龄的模型中才会发现相关性。终末分化的 CD4+ 和 CD8+ T 细胞在任何模型中都没有发现明显的关联:我们发现乐观情绪和生活目标与幼稚 CD4+ T 细胞百分比有关。
Relations of optimism and purpose in life to immune markers in aging
Objective
Optimism and purpose in life are associated with improved health outcomes. More information is needed on biological mechanisms, including immunosenescence. We investigated if psychological well-being is associated with healthier immunosenescence-related measures including naïve and terminally differentiated CD4+ and CD8+ T cell percentages, CD4+:CD8+, and cytomegalovirus (CMV) IgG response.
Methods
Participants were adults over age 50 from the Health and Retirement Study. Optimism was measured using the Life Orientation Test Revised. Purpose in life was assessed using the subscale from the Ryff psychological well-being measure. We examined the cross-sectional associations of optimism and purpose in life with measures of T cell subsets using linear regression and with CMV IgG using ordered logit regression, controlling for potential confounding factors.
Results
The final analytic sample ranged from 7250 to 7870. After adjusting for sociodemographic factors, a 1-SD increment in optimism was associated with the percentage of naïve CD4+ T cells increasing by 0.6 (95%CI 0.2%, 1.0%). A 1-SD increment in purpose in life was associated with the percentage of naïve CD4+ T cells increasing by 0.9 (95%CI 0.5%, 1.3%) after adjusting for sociodemographic factors and the association was maintained after further adjustments for health conditions, depression, and health behaviors. For naïve CD8+ T cell percentages, CD4:CD8 ratios, and CMV IgG antibodies, associations were seen only in models that adjusted for age. No significant associations were seen in any models for the terminally differentiated CD4+ and CD8+ T cells.
Conclusions
We found associations of optimism and purpose in life with naïve CD4+ T cell percentages.
期刊介绍:
The Journal of Psychosomatic Research is a multidisciplinary research journal covering all aspects of the relationships between psychology and medicine. The scope is broad and ranges from basic human biological and psychological research to evaluations of treatment and services. Papers will normally be concerned with illness or patients rather than studies of healthy populations. Studies concerning special populations, such as the elderly and children and adolescents, are welcome. In addition to peer-reviewed original papers, the journal publishes editorials, reviews, and other papers related to the journal''s aims.