Jacob Denton , Hasan Ozgur , Pantea Sazegar , John Galgiani , Talha Riaz
{"title":"一名服用芬戈莫德的多发性硬化症患者的肌肉骨骼和中枢神经系统球孢子菌病--病例报告","authors":"Jacob Denton , Hasan Ozgur , Pantea Sazegar , John Galgiani , Talha Riaz","doi":"10.1016/j.idcr.2024.e02021","DOIUrl":null,"url":null,"abstract":"<div><p>We report the case of a 56-year-old female with a past medical history of multiple sclerosis on disease-modifying therapy of fingolimod who presented with disseminated <em>Coccidioides</em> infection, initially of the ankles bilaterally before progressing to the central nervous system. CNS coccidiomycosis has thus far not been associated with any pharmacological therapy for multiple sclerosis. Clinicians should have a high degree of suspicion for <em>Coccidioides</em> infection in immunosuppressed patients living in endemic areas.</p></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":"37 ","pages":"Article e02021"},"PeriodicalIF":1.1000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214250924000970/pdfft?md5=5b9b0026939e5d20eb9f586451c6cd25&pid=1-s2.0-S2214250924000970-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Musculoskeletal and CNS coccidiomycosis in an individual with multiple sclerosis on fingolimod – A case report\",\"authors\":\"Jacob Denton , Hasan Ozgur , Pantea Sazegar , John Galgiani , Talha Riaz\",\"doi\":\"10.1016/j.idcr.2024.e02021\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>We report the case of a 56-year-old female with a past medical history of multiple sclerosis on disease-modifying therapy of fingolimod who presented with disseminated <em>Coccidioides</em> infection, initially of the ankles bilaterally before progressing to the central nervous system. CNS coccidiomycosis has thus far not been associated with any pharmacological therapy for multiple sclerosis. Clinicians should have a high degree of suspicion for <em>Coccidioides</em> infection in immunosuppressed patients living in endemic areas.</p></div>\",\"PeriodicalId\":47045,\"journal\":{\"name\":\"IDCases\",\"volume\":\"37 \",\"pages\":\"Article e02021\"},\"PeriodicalIF\":1.1000,\"publicationDate\":\"2024-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2214250924000970/pdfft?md5=5b9b0026939e5d20eb9f586451c6cd25&pid=1-s2.0-S2214250924000970-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"IDCases\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2214250924000970\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"IDCases","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2214250924000970","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
Musculoskeletal and CNS coccidiomycosis in an individual with multiple sclerosis on fingolimod – A case report
We report the case of a 56-year-old female with a past medical history of multiple sclerosis on disease-modifying therapy of fingolimod who presented with disseminated Coccidioides infection, initially of the ankles bilaterally before progressing to the central nervous system. CNS coccidiomycosis has thus far not been associated with any pharmacological therapy for multiple sclerosis. Clinicians should have a high degree of suspicion for Coccidioides infection in immunosuppressed patients living in endemic areas.
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