选择性地向内质网或高尔基体输送成像探针和治疗剂:当前战略及其他。

IF 15.2 1区 医学 Q1 PHARMACOLOGY & PHARMACY Advanced drug delivery reviews Pub Date : 2024-07-04 DOI:10.1016/j.addr.2024.115386
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引用次数: 0

摘要

内质网(ER)或高尔基体(GA)是向其他细胞器和质膜传递细胞构建/信号成分(如蛋白质、脂质、Ca2+)的枢纽,因此,为了最大限度地提高治疗效果并减少不必要的影响,最近人们对靶向内质网(ER)或高尔基体(GA)的药物越来越感兴趣。它们的结构或功能损伤会诱发细胞器应激(即 ER 或 GA 应激),其恶化与疾病(如癌症、肝病、脑病)密切相关。目前已经开展了许多工作,对目标细胞器的(病理)生理功能(如氧化应激、蛋白质/脂质相关处理)和特征(如 pH 值、温度、生物硫醇、活性氧)进行成像,并利用细胞器靶向分子递送药物以破坏细胞器。因此,本综述将概述相关细胞器的结构、(病理)生理功能/特征以及相关疾病。通过了解目前在靶向、成像/传感和治疗策略方面的策略和研究,将讨论ER或GA靶向的未来方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Selective delivery of imaging probes and therapeutics to the endoplasmic reticulum or Golgi apparatus: Current strategies and beyond

To maximize therapeutic effects and minimize unwanted effects, the interest in drug targeting to the endoplasmic reticulum (ER) or Golgi apparatus (GA) has been recently growing because two organelles are distributing hubs of cellular building/signaling components (e.g., proteins, lipids, Ca2+) to other organelles and the plasma membrane. Their structural or functional damages induce organelle stress (i.e., ER or GA stress), and their aggravation is strongly related to diseases (e.g., cancers, liver diseases, brain diseases). Many efforts have been developed to image (patho)physiological functions (e.g., oxidative stress, protein/lipid-related processing) and characteristics (e.g., pH, temperature, biothiols, reactive oxygen species) in the target organelles and to deliver drugs for organelle disruption using organelle-targeting moieties. Therefore, this review will overview the structure, (patho)physiological functions/characteristics, and related diseases of the organelles of interest. Future direction on ER or GA targeting will be discussed by understanding current strategies and investigations on targeting, imaging/sensing, and therapeutic systems.

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来源期刊
CiteScore
28.10
自引率
5.00%
发文量
294
审稿时长
15.1 weeks
期刊介绍: The aim of the Journal is to provide a forum for the critical analysis of advanced drug and gene delivery systems and their applications in human and veterinary medicine. The Journal has a broad scope, covering the key issues for effective drug and gene delivery, from administration to site-specific delivery. In general, the Journal publishes review articles in a Theme Issue format. Each Theme Issue provides a comprehensive and critical examination of current and emerging research on the design and development of advanced drug and gene delivery systems and their application to experimental and clinical therapeutics. The goal is to illustrate the pivotal role of a multidisciplinary approach to modern drug delivery, encompassing the application of sound biological and physicochemical principles to the engineering of drug delivery systems to meet the therapeutic need at hand. Importantly the Editorial Team of ADDR asks that the authors effectively window the extensive volume of literature, pick the important contributions and explain their importance, produce a forward looking identification of the challenges facing the field and produce a Conclusions section with expert recommendations to address the issues.
期刊最新文献
Editorial Board Preface: RNA delivery technologies: From concept toward the clinic Delivery and kinetics of immersion optical clearing agents in tissues: Optical imaging from ex vivo to in vivo Extracellular vesicles versus lipid nanoparticles for the delivery of nucleic acids Corrigendum to “Editorial: Advanced strategies to bridge the gap between inflammation and tissue regeneration” [Adv. Drug Deliv. Rev. 209 (2024) 115328]
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