胚胎质量对第 5 天与第 6 天单倍体囊胚移植妊娠结局的影响:回顾性队列研究。

IF 2.3 Q2 OBSTETRICS & GYNECOLOGY International Journal of Fertility & Sterility Pub Date : 2024-06-09 DOI:10.22074/ijfs.2023.2006100.1488
Le Duc Thang, Minh Nguyen Thuy, Chi Tham Dung, Thi Tu Phi Anh, Ngoc Phan Quy, Thi Vu Ngoc, Mai Ha Linh, Le Nguyen Thuy, Tuan Cao Anh, Thu Tran Thuy, Thi Lien Nguyen Huong, Le Hoang, Jean Noel Hugues
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引用次数: 0

摘要

背景:选择植入潜力最大的胚胎对体外受精(IVF)的成功至关重要。胚胎着床时间(第 5 天或第 6 天)和胚胎质量都被认为是决定单个优倍囊胚移植临床结果的影响因素。然而,支持 D5 囊胚优于 D6 囊胚的证据仍无定论。本研究旨在比较不同质量和不同胚泡着床时间的单倍囊胚移植后的临床结果:我们的辅助生殖中心进行了一项回顾性队列研究,分析了2019年1月至2022年2月期间进行的774例D5型极胚移植和155例D6型极胚移植的结果:结果:优生D6组的活产率明显低于优生D5组(38.71%对55.04%,P=0.001)。胚胎质量对结果有很大影响。D5 和 D6 优良胚胎移植后的活产率分别为 62.14% 和 53.61%,D5 和 D6 良好胚胎移植后的活产率分别为 45.18% 和 32.21%,而 D5 和 D6 一般胚胎移植后的活产率仅为 28.64% 和 19.32%。不同胚胎质量类别的结果差异具有统计学意义(P=0.001)。临床结果的调整风险比(RR)表明,优倍体 D5 胚胎的表现始终优于其他类型的胚胎质量:结论:胚胎着床时间和胚胎质量是决定单个优倍性囊胚移植成功与否的关键因素。优秀的优倍D5胚胎移植产生了卓越的临床结果,为试管婴儿团队和患者选择胚胎移植提供了宝贵的见解。
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The Impact of Embryo Quality on Pregnancy Outcomes in Single Day 5 versus Day 6 Euploid Blastocyst Transfer: A Retrospective Cohort Study.

Background: Selecting embryos with the highest implantation potential is crucial for in vitro fertilization (IVF) success. Both the timing of blastulation, day 5 (D5) or D6, and the embryo quality have been suggested as influential factors in determining the clinical outcome of single euploid blastocyst transfers. However, evidence supporting the superiority of D5 over D6 blastocysts remains inconclusive. The aim of this study was to compare clinical outcomes following the transfer of euploid blastocysts with different quality and timing of blastulation.

Materials and methods: A retrospective cohort study was conducted at our Assisted Reproductive Center, analyzing the outcome of 774 transfers with D5 euploids and 155 transfers with D6 euploids performed between January 2019 and February 2022.

Results: The live birth rate was significantly lower in the euploid D6 group compared to the euploid D5 group (38.71vs. 55.04%, P=0.001). The outcome was significantly influenced by the quality of the embryos. Live birth rates were 62.14 and 53.61% following transfers of D5 and D6 excellent embryos respectively, 45.18 and 32.21% following transfer of D5 and D6 good embryos but only 28.64 and 19.32% following transfer of D5 and D6 fair embryos. The outcome difference was statistically significant across embryo quality categories (P=0.001). The adjusted risk ratios (RR) of clinical outcomes indicated that excellent euploid D5 embryos consistently outperformed other types of embryo quality.

Conclusion: The timing of blastulation and embryo quality are crucial factors in determining the success of single euploid blastocyst transfers. Excellent euploid D5 transfers yielded superior clinical outcomes, providing valuable insights for IVF teams and patients when selecting embryos to be transferred.

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来源期刊
CiteScore
4.20
自引率
0.00%
发文量
68
审稿时长
>12 weeks
期刊介绍: International Journal of Fertility & Sterility is a quarterly English publication of Royan Institute . The aim of the journal is to disseminate information through publishing the most recent scientific research studies on Fertility and Sterility and other related topics. Int J Fertil Steril has been certified by Ministry of Culture and Islamic Guidance in 2007 and was accredited as a scientific and research journal by HBI (Health and Biomedical Information) Journal Accreditation Commission in 2008. Int J Fertil Steril is an Open Access journal.
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