彻底改变药物发现:利用生物标志物进行精准医疗和靶向治疗

Rhea Vinod Nair, K. S
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摘要

药物发现仍然是一个复杂而耗时的过程,常常受到效率低下和高失败率的阻碍。生物标志物作为生物过程的可测量指标,已成为彻底改变这一局面的有力工具。本文探讨了生物标记物在整个药物发现过程中的多方面作用,从靶点识别、药物开发到临床试验和患者分层。我们强调了生物标记物如何增强我们对疾病机理的理解、促进有前途候选药物的筛选以及实现对药物疗效和安全性的客观评估。此外,将生物标记物与辅助诊断相结合,可实现个性化医疗方法,使治疗方案符合患者的个体需求。我们讨论了药物发现中使用的各类生物标记物,包括基因组、蛋白质组和成像生物标记物,同时也承认了与这些标记物的验证和监管审批相关的挑战。总之,战略性地利用生物标记物在简化药物发现、加快研发进度以及最终为患者提供更安全、更有效的疗法方面具有巨大的潜力。
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REVOLUTIONIZING DRUG DISCOVERY: UTILIZING BIOMARKERS FOR PRECISION MEDICINE AND TARGETED THERAPIES
Drug discovery remains a complex and time-consuming process, often hindered by inefficiencies and high failure rates. Biomarkers, measurable indicators of biological processes, have emerged as powerful tools to revolutionize this landscape. This article explores the multifaceted role of biomarkers throughout the drug discovery, from target identification and drug development to clinical trials and patient stratification. We highlight how biomarkers enhance our understanding of disease mechanisms, facilitate the selection of promising drug candidates, and enable objective assessment of drug efficacy and safety. Furthermore, the integration of biomarkers with companion diagnostics allows for personalized medicine approaches, tailoring treatment options to individual patient needs. We discuss the various types of biomarkers employed in drug discovery, including genomic, proteomic, and imaging biomarkers, while acknowledging the challenges associated with their validation and regulatory approval. In conclusion, the strategic utilization of biomarkers holds immense potential to streamline drug discovery, accelerate development timelines, and ultimately bring safer and more effective therapies to patients.
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