计算机断层扫描、超声波和正电子发射断层扫描--淋巴瘤计算机断层扫描独立检测和联合检测的诊断和预后价值。

IF 2.5 4区 医学 Q3 BIOCHEMICAL RESEARCH METHODS SLAS Technology Pub Date : 2024-08-01 DOI:10.1016/j.slast.2024.100165
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引用次数: 0

摘要

淋巴瘤是一种起源于淋巴造血系统的恶性肿瘤,可影响人体的所有组织和器官。淋巴瘤具有高度异质性,治疗效果差异很大。不同病理类型和分期的淋巴瘤在治疗强度和预后方面差异很大。淋巴瘤的早期诊断对改善患者的预后非常重要。因此,本研究探讨了计算机断层扫描(CT)、超声和正电子发射断层扫描-计算机断层扫描(PET-CT)独立检测和联合检测对淋巴瘤的诊断价值。PET-CT组和联合组的敏感性、特异性、阳性预测值(PPV)和阴性预测值(NPV)均大大高于CT组和超声组,差异明显(P<0.05)。CT组、B超组、PET-CT组和联合组的曲线下面积(AUC)值分别为0.632(P=0.032)、0.614(P=0.025)、0.793(P=0.002)和0.859(P=0.001),表现出明显的差异(P<0.05)。PET/CT对淋巴瘤的敏感性和特异性均高于CT和B超,可明确显示淋巴淋巴瘤的早期轻度结果。因此,PET/CT联合诊断淋巴淋巴瘤具有较高的临床价值。
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Diagnostic and prognostic value of independent and combined detection of computed tomography, ultrasound, and positron emission tomography - computed tomography in lymphoma

Lymphoma is a malignant tumor originating from the lymphopoietic system, which can affect all tissues and organs of the body. Lymphoma is highly heterogeneous and the therapeutic effect varies greatly. Different pathological types and stages of lymphoma differ greatly in terms of treatment intensity and prognosis. Early diagnosis of lymphoma is very important to improve the prognosis of patients. Therefore, this work explored the diagnostic value of independent and combined detection of computed tomography (CT), ultrasound, and positron emission tomography - computed tomography (PET-CT) for lymphoma. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) in the PET-CT and combination groups were greatly higher than those in the CT and ultrasound groups, showing obvious differences (P < 0.05). The area under curve (AUC) values in the CT group, ultrasound group, PET-CT group, and combination group were 0.632 (P = 0.032), 0.614 (P = 0.025), 0.793 (P = 0.002), and 0.859 (P = 0.001), respectively, exhibiting observable differences (P < 0.05). the sensitivity and specificity of PET/CT for lymphoma were higher than those of CT and ultrasound, which can clearly show the early mild results of lymphatic lymphoma. Therefore, the combined diagnosis of lymphatic lymphoma with PET/CT was of high clinical value.

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来源期刊
SLAS Technology
SLAS Technology Computer Science-Computer Science Applications
CiteScore
6.30
自引率
7.40%
发文量
47
审稿时长
106 days
期刊介绍: SLAS Technology emphasizes scientific and technical advances that enable and improve life sciences research and development; drug-delivery; diagnostics; biomedical and molecular imaging; and personalized and precision medicine. This includes high-throughput and other laboratory automation technologies; micro/nanotechnologies; analytical, separation and quantitative techniques; synthetic chemistry and biology; informatics (data analysis, statistics, bio, genomic and chemoinformatics); and more.
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