噬菌体诱导可促进多细胞链霉菌结构的体外扩散。

IF 9.8 1区生物学 Q1 Agricultural and Biological Sciences PLoS Biology Pub Date : 2024-07-25 eCollection Date: 2024-07-01 DOI:10.1371/journal.pbio.3002725

Hoda Jaffal, Mounia Kortebi, Pauline Misson, Paulo Tavares, Malika Ouldali, Hervé Leh, Sylvie Lautru, Virginia S Lioy, François Lecointe, Stéphanie G Bury-Moné

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引用次数: 0

摘要

链霉菌以大量生产特殊代谢物而闻名，在医药和农业中都有应用。这些多细胞细菌具有复杂的发育周期，在土壤生态学中发挥着关键作用。人们对链霉菌噬菌体对细菌生理的影响知之甚少。在这项研究中，我们调查了 "Samy "噬菌体的表达和产生条件，"Samy "是安博法氏链霉菌（Streptomyces ambofaciens ATCC 23877）中的一种噬菌体。这种噬菌体是与其他移动遗传因子的激活同时产生的。值得注意的是，Samy 的存在和产生增加了细菌在体外压力条件下的扩散。总之，这项研究揭示了噬菌体感染在多细胞聚集动态中的一种新特性。

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Prophage induction can facilitate the in vitro dispersal of multicellular Streptomyces structures.

Streptomyces are renowned for their prolific production of specialized metabolites with applications in medicine and agriculture. These multicellular bacteria present a sophisticated developmental cycle and play a key role in soil ecology. Little is known about the impact of Streptomyces phage on bacterial physiology. In this study, we investigated the conditions governing the expression and production of "Samy", a prophage found in Streptomyces ambofaciens ATCC 23877. This siphoprophage is produced simultaneously with the activation of other mobile genetic elements. Remarkably, the presence and production of Samy increases bacterial dispersal under in vitro stress conditions. Altogether, this study unveiled a new property of a bacteriophage infection in the context of multicellular aggregate dynamics.

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来源期刊

PLoS Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-BIOLOGY

CiteScore

15.40

自引率

2.00%

发文量

359

审稿时长

3-8 weeks

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