Kimia Daneshvar, Mohammadreza Akhlaghi, Shila Iranpour, Matin Irajpour, Mohsen Pourazizi
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引用次数: 0
摘要
背景：本综述旨在证实医学文献中维生素 D 与视网膜静脉闭塞（RVO）的相关性：本综述旨在证实医学文献中维生素 D 与视网膜静脉闭塞（RVO）之间的相关性：截至 2023 年 12 月 10 日，在 PubMed、SCOPUS、Web of Science 和 Embase 上进行了系统综述和荟萃分析。通过细致的文献检索，确定并分析了所有报道 RVO 患者维生素 D 水平的观察分析性论文。主要结果测量指标集中在对RVO患者（病例）和无RVO患者（对照）的维生素D水平进行比较评估。研究方案已在 PROSPERO 注册（代码：CRD42024499853）：本次荟萃分析共纳入了六项相关研究，共有 589 名参与者。结果表明，维生素 D 缺乏与 RVO 风险增加之间存在显著关联（Odds ratio = 14.51；95% CI：[1.71, 122.59]，P = 0.014）；RVO 患者的血清维生素 D 水平显著下降 1.91ng/mL （95% CI：[-2.29, -1.54]，P 结论：RVO 患者的维生素 D 水平较高：与健康对照组相比，RVO 患者更缺乏维生素 D。这些结果为越来越多的证据做出了贡献，这些证据强调了补充维生素 D 作为 RVO 预防和治疗策略的复杂作用：CRD42024499853。
Vitamin D deficiency in patients with retinal vein occlusion: a systematic review and meta-analysis.
Background: This review aims to substantiate the correlation between vitamin D and retinal vein occlusion (RVO) within the medical literature.
Method: A systematic review and meta-analysis were conducted in PubMed, SCOPUS, Web of Science, and Embase until December 10th, 2023. A meticulous literature search was undertaken to identify and analyze all observational-analytical papers reporting vitamin D levels in RVO patients. The principal outcome measures centered on the comparative assessment of vitamin D levels between patients with RVO (cases) and those devoid of RVO (controls). The protocol was registered in PROSPERO (code: CRD42024499853).
Results: A total of six relevant studies consisting of 589 participants were included in this meta-analysis. The results indicated a significant association between vitamin D deficiency and increased risk of RVO (Odds ratio = 14.51; 95% CI: [1.71, 122.59], P = 0.014); and patients with RVO exhibited a significant decrease in serum vitamin D levels by 1.91ng/mL (95% CI: [-2.29, -1.54], P < 0.001). Moreover, there was no significant difference observed in vitamin D levels between central RVO (CRVO) and branch RVO (BRVO) subtypes (P = 0.63).
Conclusion: RVO patients have more vitamin D deficiency than healthy controls. These results contribute to the growing body of evidence highlighting the intricate role of vitamin D supplementation as both a prophylactic and a treatment strategy in RVO.
期刊介绍：
International Journal of Retina and Vitreous focuses on the ophthalmic subspecialty of vitreoretinal disorders. The journal presents original articles on new approaches to diagnosis, outcomes of clinical trials, innovations in pharmacological therapy and surgical techniques, as well as basic science advances that impact clinical practice. Topical areas include, but are not limited to: -Imaging of the retina, choroid and vitreous -Innovations in optical coherence tomography (OCT) -Small-gauge vitrectomy, retinal detachment, chromovitrectomy -Electroretinography (ERG), microperimetry, other functional tests -Intraocular tumors -Retinal pharmacotherapy & drug delivery -Diabetic retinopathy & other vascular diseases -Age-related macular degeneration (AMD) & other macular entities
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