Philippe Codron, Stéphanie Millecamps, Philippe Corcia
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引用次数: 0
摘要
确定肌萎缩性脊髓侧索硬化症（ALS）的生物标志物是疾病研究的核心问题。Chatterjee 等人在最近的一篇文章中指出，血液细胞外囊泡 (EVs) 中含有高水平的转录反应 DNA 结合蛋白 43 (TDP-43)，能准确地区分 ALS 患者和对照组，并与疾病严重程度相关，为早期诊断和监测提供了一种很有前景的生物标记物。
EVolution in ALS diagnosis: molecular markers in extracellular vesicles.
The identification of biomarkers for amyotrophic lateral sclerosis (ALS) is a central issue in disease research. In a recent article, Chatterjee et al. show that blood extracellular vesicles (EVs) with high levels of transactive response DNA-binding protein 43 (TDP-43) accurately discriminate patients with ALS from controls and correlate with disease severity, providing a promising biomarker for early diagnosis and monitoring.
期刊介绍：
Trends in Molecular Medicine (TMM) aims to offer concise and contextualized perspectives on the latest research advancing biomedical science toward better diagnosis, treatment, and prevention of human diseases. It focuses on research at the intersection of basic biology and clinical research, covering new concepts in human biology and pathology with clear implications for diagnostics and therapy. TMM reviews bridge the gap between bench and bedside, discussing research from preclinical studies to patient-enrolled trials. The major themes include disease mechanisms, tools and technologies, diagnostics, and therapeutics, with a preference for articles relevant to multiple themes. TMM serves as a platform for discussion, pushing traditional boundaries and fostering collaboration between scientists and clinicians. The journal seeks to publish provocative and authoritative articles that are also accessible to a broad audience, inspiring new directions in molecular medicine to enhance human health.
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