聚（ADP-核糖）：调节癌细胞存活和死亡的双刃剑

IF 2.6 Q3 ONCOLOGY World journal of clinical oncology Pub Date : 2024-07-24 DOI:10.5306/wjco.v15.i7.806

Keun-Yeong Jeong, Ji-Hyuk Kang

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引用次数: 0

摘要

聚（ADP-核糖）（PAR）是 ADP-核糖的聚合物，由 PAR 聚合酶合成，由于其在 DNA 修复和翻译后修饰方面的重要功能，对癌细胞的存活至关重要。除了其辅助作用外，PAR 还能通过过度积累 PAR 引发能量危机和副胰岛素，从而导致癌细胞死亡。这一现象凸显了以 PAR 调控为靶点作为新型抗癌策略的潜力，其原理也将成为抗癌研究领域一个引人入胜的话题。因此，本社论概述了决定癌细胞命运的机制，强调了 PAR 的核心作用。它进一步介绍了调节 PAR 浓度的可行方法，这些方法可能为创新抗癌疗法铺平道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Poly (ADP-ribose): A double-edged sword governing cancer cell survival and death.

Poly (ADP-ribose) (PAR), a polymer of ADP-ribose, is synthesized by PAR polymerase and is crucial for the survival of cancer cells due to its vital functions in DNA repair and post-translational modifications. Beyond its supportive role, PAR also triggers cancer cell death by excessive accumulation of PAR leading to an energy crisis and parthanatos. This phenomenon underscores the potential of targeting PAR regulation as a novel anticancer strategy, and the rationale would present an engaging topic in the field of anticancer research. Therefore, this editorial provides an overview of the mechanisms determining cancer cell fate, emphasizing the central role of PAR. It further introduces promising methods for modulating PAR concentrations that may pave the way for innovative anticancer therapies.

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来源期刊

World journal of clinical oncology ONCOLOGY-

自引率

0.00%

发文量

585

期刊介绍： The WJCO is a high-quality, peer reviewed, open-access journal. The primary task of WJCO is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of oncology. In order to promote productive academic communication, the peer review process for the WJCO is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJCO are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in oncology. Scope: Art of Oncology, Biology of Neoplasia, Breast Cancer, Cancer Prevention and Control, Cancer-Related Complications, Diagnosis in Oncology, Gastrointestinal Cancer, Genetic Testing For Cancer, Gynecologic Cancer, Head and Neck Cancer, Hematologic Malignancy, Lung Cancer, Melanoma, Molecular Oncology, Neurooncology, Palliative and Supportive Care, Pediatric Oncology, Surgical Oncology, Translational Oncology, and Urologic Oncology.