肠道移植中的 B 细胞诱导疗法

IF 3.7 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Gastroenterology Clinics of North America Pub Date : 2024-09-01 Epub Date: 2024-04-06 DOI:10.1016/j.gtc.2024.01.001
Jennifer Garcia MD , Rodrigo Vianna MD
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引用次数: 0

摘要

尽管自肠道移植开始以来在短期疗效方面取得了进步,但长期移植失败的情况依然严重。早期的成功归功于他克莫司(tacrolimus)的维持治疗和T细胞调节诱导疗法,这两种疗法有效降低了急性细胞排斥反应的发生率。然而,慢性异体移植损伤的难题仍未解决。越来越多的证据表明,供体特异性抗体与内脏异体移植物的存活率之间存在相关性。旨在减少这些抗体的存在或负荷的策略有可能提高长期疗效。因此,我们现在将重点转向 B 细胞诱导疗法,将其作为一种可能的解决方案。
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B-Cell Induction Therapies in Intestinal Transplantation
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来源期刊
CiteScore
6.60
自引率
0.00%
发文量
77
审稿时长
6-12 weeks
期刊介绍: Gastroenterology Clinics of North America updates you on the latest trends in patient management; keeps you up to date on the newest advances; and provides a sound basis for choosing treatment options. Each issue focuses on a single topic in gastroenterology and is presented under the direction of an experienced guest editor.
期刊最新文献
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