{"title":"肠道移植中的 B 细胞诱导疗法","authors":"Jennifer Garcia MD , Rodrigo Vianna MD","doi":"10.1016/j.gtc.2024.01.001","DOIUrl":null,"url":null,"abstract":"","PeriodicalId":55129,"journal":{"name":"Gastroenterology Clinics of North America","volume":null,"pages":null},"PeriodicalIF":2.9000,"publicationDate":"2024-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"B-Cell Induction Therapies in Intestinal Transplantation\",\"authors\":\"Jennifer Garcia MD , Rodrigo Vianna MD\",\"doi\":\"10.1016/j.gtc.2024.01.001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"\",\"PeriodicalId\":55129,\"journal\":{\"name\":\"Gastroenterology Clinics of North America\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2024-04-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Gastroenterology Clinics of North America\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0889855324000013\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"GASTROENTEROLOGY & HEPATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Gastroenterology Clinics of North America","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0889855324000013","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
尽管自肠道移植开始以来在短期疗效方面取得了进步,但长期移植失败的情况依然严重。早期的成功归功于他克莫司(tacrolimus)的维持治疗和T细胞调节诱导疗法,这两种疗法有效降低了急性细胞排斥反应的发生率。然而,慢性异体移植损伤的难题仍未解决。越来越多的证据表明,供体特异性抗体与内脏异体移植物的存活率之间存在相关性。旨在减少这些抗体的存在或负荷的策略有可能提高长期疗效。因此,我们现在将重点转向 B 细胞诱导疗法,将其作为一种可能的解决方案。
期刊介绍:
Gastroenterology Clinics of North America updates you on the latest trends in patient management; keeps you up to date on the newest advances; and provides a sound basis for choosing treatment options. Each issue focuses on a single topic in gastroenterology and is presented under the direction of an experienced guest editor.