STRUCTURAL AND FUNCTIONAL CHANGES IN ANIMAL ORGANS UNDER THE ACTION OF THE COMPONENT «SILYBUM MARIANUM (L.) Gaertn.» IN OBESITY

To date, despite the huge success in the creation of synthetic drugs, a large number of medicinal preparations approved for use in scientific medicine include the active substances of higher plants. Medicinal plants are little studied and are a source for studying their use as a remedy. The use of any drug without knowledge of all its pharmacological effects is unacceptable. For modern medicine and pharmacy, the search for drugs with hepatoprotective activity still does not lose its relevance. This article presents information regarding the efficacy and safety of the use of silymarin in patients with acute toxic, including drug-induced, and chronic liver damage. In this regard, there is a need to study the currently available information on the composition, pharmacokinetics, mechanisms of action of Silybum marianum (L.) Gaertn., as well as its effectiveness in common diseases. The results of studies and systematic reviews of the use of silymarin in acute and chronic liver damage of toxic and infectious pathology indicate the high efficiency and safety of this drug in case of poisoning by toxic substances. At the same time, the question of the use of this plant as a dietary supplement remains not fully understood. At present, the dynamics of regeneration processes under physiological conditions, with injuries and various pathologies of tissues, has been quite fully studied and described. However, the regenerative processes at the cellular and subcellular level in obesity remain insufficiently studied, which makes it possible to describe in more detail the essence of regenerative processes, the ability to develop new methods for preserving the vital organ for the body, such as the liver and kidneys.